Estimation of malondialdehyde (MDA)‎ levels and the relationship with homocysteine and serum copper in beta-thalassemia patients

الملخص EN

The study was designed to evaluate the medical relevance of hyperhomocysteinemia and copper levels with malondialdehyde in beta-thalassemia patients .

Blood samples were taken from thalassemia departments of a ministry of healthy hospitals.

Fifty children with thalassemia (study group) and fifty healthy controls (group control).

We found that significantly increased lipid peroxidation, measured as MDA, was demonstrated in thalassemia (p < 0.01).

The mean plasma homocysteine (thcy) level in children with thalassemia was significantly higher than the control group (p < 0.02) In addition, the mean serum copper level in thalassemia patients was significantly higher than the control group (p < 0.03).

Moreover, a positive correlation was also observed between homocysteine, copper with MDA levels in the patient group but not in the control group.