Comparative pharmacokineticpharmacodynamic integration of enrofloxacin with marbofloxacin in goats

الملخص EN

Comparative pharmacokinetic / pharmacodynamic integration of enrofloxacin (5.0 mg / kg.

b.

wt.) with marbofloxacin (2.0 mg / kg.b.wt.) were studied after intramuscular administration in goats. The two drugs were rapidly absorbed within 1 hour and achieved average peak plasma concentration 1.18 ± 0.04 μg / ml for enrofloxacin and 1.37 ± 0.07 μg / ml for marbofloxacin, while, the area under plasma concentration-time curve (AUC0-24) was 5.10 ± 0.25 and 6.90 ± 0.38 μg / ml.

h for enrofloxacin and marbofloxacin respectively. Pharmacokinetic/pharmacodynamic integration parameters was expressed as maximum plasma concentration / minimum inhibitory concentration (Cmax / MIC) and the area under plasma concentration-time Curve / minimum inhibitory concentration (AUC0-24 / MIC) which reflect the antimicrobial activity as a surrogate markers. The Cmax / MIC ratio was 19.67 ± 0.11 for enrofloxacin and 11.42 ± 0.16 for marbofloxacin (both exceed the Cmax / MIC ratio ; >10), while, the AUC0- 24 / MIC ratio was 85.00 ± 3.90 and 57.50 ± 2.18 for enrofloxacin and marbofloxacin, respectively (but not exceed the AUC0-24 / MIC ratio ; >125). Enrofloxacin exhibited superior pharmacokinetic / pharmacodynamic integration compared with marbofloxacin for E.

Coli infection in goats.