Some serum lipid profile and glucose levels pre- and post-cholecystectomy

الملخص EN

Objectives: To determine the changes in some lipid profile parameters and glucose level in serum in gall stone patients before, after one week and after one month of cholecystectomy, in order to evaluate the effect of cholecystectomy on the parameters measured. Patients and Methods: Sixty patients (19 males and 41 Females) age range from (22-79) years, with a mean of (43) years were included in this study.

All of them underwent cholecystectomy in either of two Hospitals (AL-Zahrawae General Hospital and Ninevah Private Hospital) during a period of six months from 1st October 2004 to 31st March 2005. Blood samples were collected from all subjects in this study.

Serum was separated by centrifugation for the measurement of fasting glucose, total cholesterol, triglycerides, HDL-cholesterol, LDL-cholesterol and atherogenic index. Results: The results of the data analyzed are presented according to the intervals at which the samples were obtained from the patients as follows: 1.

Day of cholecystectomy. 2.

After 1 week of cholecystectomy. 3.

After 1 month of cholecystectomy. Total cholesterol (TC): It is found that there is a significant reduction in TC (P < 0.01) in both intervals after cholecystectomy when compared to that before operation.

HDL-c: It is found that there is a significant increase in HDL-c (P < 0.01) in both intervals after cholecystectomy when compared to that before operation. LDL-c: It is found that there is a significant decrease in LDL-c (P < 0.01) in both intervals after cholecystectomy when compared to that before operation. TG: It is found that there is a significant reduction in TG (P < 0.01) in both intervals after cholecystectomy when compared to that before operation. AI: It is found that there is a significant reduction in AI (P < 0.01) in both intervals after cholecystectomy when compared to that before operation. FG: It is found that there is a significant increase in FG (P < 0.01) in both intervals after cholecystectomy when compared to that before operation. Conclusion: Gall stone is an important cause to significant pathological changes in some lipid profile parameters, these parameters will return toward normal after cholecystectomy.

This normalization will increase with the time.