Effect of trifolium sp. Flowers extracts on the status of liver histology of streptozotocin-induced diabetic rats

الملخص EN

The present study deals with the effect of (water, hexane and ethanol) extracts prepared from the flower head of clover flowers (CF) (Trifolium alexandrinum), in the treatment of diabetes induced experimentally by streptozotocin (STZ) in male rats.

More than fifty percent of diabetic rats were died by 48 hours post streptozotocin injection.

A single dose of STZ (50mg / kg body weight) induced destruction of the liver architecture, cytoplasmic vacuolation of the hepatocytes and nuclei of many cells revealed clear signs of necrosis, leucocytic infiltration, liver fibrosis and fatty infiltration.

Moreover, Dilatation and inflammation in central vein and blood vessels, the portal veins appeared congested with blood with fibrosis and leucocytic infiltration around it.

After treatment with water, hexan and ethanol extracts of CF remarkable improvement in histological structure of liver sections of diabetic rats, the water extract is more potent than hexane and ethanol extracts.

Thus, the result of the present study provides a scientific rationale for the use of Trifolium alexandrinum as promising antidiabetic agent.