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Effect of atiko ( aframomum sceptrum) and african nutmeg (monodora myristica) on reduced glutathione, uric acid levels and liver marker enzymes in strep tozotocininduced diabetic rats
المؤلفون المشاركون
Osioma, B.O.George E.
Falodun, A.
المصدر
The Egyptian Journal of Biochemistry and Molecular Biology
العدد
المجلد 28، العدد 2 (31 ديسمبر/كانون الأول 2010)، ص ص. 67-78، 12ص.
الناشر
الجمعية المصرية للكيمياء الحيوية و البيولوجيا الجزيئية
تاريخ النشر
2010-12-31
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الموضوعات
الملخص EN
This study investigated the effect of the methanolic extract of Aframomum sceptrum and Monodora myristica on the reduced glutathione (GSH) and uric acid levels in the plasma and liver of streptozotocin (STZ)-induced-diabetic rats.
The possible hepatic damage resulting from the administration of the spices was also examined.
(Thirty-two Wistar albino rats (males and females), weighing between 160g-200g were divided into eight groups (n = 4).
Four groups were made diabetic by the administration of STZ (50mg / kg body wt.) intraperiotoneally.Results obtained indicate decreased levels of blood reduced glutathione and uric acid (indices of antioxidant status) in the plasma and liver of diabetic rats, but there were significant increases in the activities of alanine and aspartate transaminases (ALT and AST) (indices of liver dysfunction).
However, oral administration of the methanolic extract of M.
myristica as well as A.
sceptrum significantly increased blood GSH content of diabetic rats.
Uric acid levels were elevated in plasma and liver of diabetic rats treated with both spices as compared with the control rats.
Similarly, ALT and AST activities decreased significantly in the plasma and liver of diabetic rats administered with the methanolic extracts.
These results suggest that the methanolic extracts of A.
sceptrum and M.
myristica may contribute to the protection against oxidative damage in STZ induced-diabetic rats without any adverse effect on the liver.
The potency of the spices as effective antioxidants is comparable to that of vitamin E, a well known and acceptable antioxidant.
Further studies on the phytochemical and toxicological properties are required to fully document the benefits of these extracts as antioxidants.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Osioma, B.O.George E.& Falodun, A.. 2010. Effect of atiko ( aframomum sceptrum) and african nutmeg (monodora myristica) on reduced glutathione, uric acid levels and liver marker enzymes in strep tozotocininduced diabetic rats. The Egyptian Journal of Biochemistry and Molecular Biology،Vol. 28, no. 2, pp.67-78.
https://search.emarefa.net/detail/BIM-240154
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Osioma, B.O.George E.& Falodun, A.. Effect of atiko ( aframomum sceptrum) and african nutmeg (monodora myristica) on reduced glutathione, uric acid levels and liver marker enzymes in strep tozotocininduced diabetic rats. The Egyptian Journal of Biochemistry and Molecular Biology Vol. 28, no. 2 (Dec. 2010), pp.67-78.
https://search.emarefa.net/detail/BIM-240154
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Osioma, B.O.George E.& Falodun, A.. Effect of atiko ( aframomum sceptrum) and african nutmeg (monodora myristica) on reduced glutathione, uric acid levels and liver marker enzymes in strep tozotocininduced diabetic rats. The Egyptian Journal of Biochemistry and Molecular Biology. 2010. Vol. 28, no. 2, pp.67-78.
https://search.emarefa.net/detail/BIM-240154
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 75-78
رقم السجل
BIM-240154
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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