Development of an immunoradiometric assay for determination of psa in benign and malignant brest tumors

الملخص EN

Total prostate specific antigen (t-PSA) levels were measured in sera and tissues of three groups of patients with breast tumors using immunoradiometric assay (IRMA).

Group I consisted of 29 women suffering from benign breast tumors.

Group II and III consisted of 21 and 27 women suffering from pre-and postmenopausal malignant breast tumors.

In addition to that, another group of 32 women were used as control.

The results obtained revealed that the levels of serum t-PSA in group I was increased significantly (P < 0.0001) whereas in group II and III, the levels of serum t- PSA were slightly significant (P < 0.05).

An immunoradiometric assay procedure was developed for the determination of t-PSA in the three groups.

Total PSA (t-PSA) level in tissues of patients with group I was significantly higher than in group II and III (p < 0.001) whereas the level of t-PSA in tissues of patients with group II and III were no significant (P < 0.1).

The results obtained revealed higher incidence of t-PSA in group I than those in group II and III.