Study of the immunological state of patients with idiopathic male infertility

الملخص EN

Unexplained infertility (Idiopathic infertility) when the pathogenesis of infertility is not yet elucidated it is often associated to immunologic factors.

This condition may be a result of auto immunity of man and woman.

Certain criteria have been applied to select the idiopathic infertile males (n = 34) enrolled in this study among the total patients attended the infertility center in Babylon.

All these patients were with normal couples.

Apparently healthy aged matched fertile men were selected as a control sample (n = 11).

Circulating immunoglobulin concentrations (IgM.

IgG, IgA) and complement components C3 and C4 were evaluated by applying Mancini single radial immunodiffusion technique for an idiopathic infertile patients and control involved in this study. Phagocytic activity as well as intracellular killing was done for both infertile patients and control.

T-cell % test was also done by E- rosette technique.

It was found that infertility was associated with an increase in IgG concentration more than normal.

Both IgM and IgG concentrations among azospermic and normospermic patients revealed an increase more than normal level.

According to the universal classification of semen abnormalities (variables) it was found that in oligospermic group patients a high significant difference in T-cell and intracellular killing compared to control.

In conclusion.

The result of immunoglobulin classes and complement components would not be a great assistance in the screening of an idiopathic male infertility although the level of IgG is more than normal level and control.

While the result of cell mediated immune parameters such as T-cell % and intracellular activity of neutrophil might be refer to the underline cause of idiopathic infertility, so the further study of cluster of differentiation (CDs), T cell subset and Lymphocytes is recommended for idiopathic infertility in combination with Antiserum Antibodies.