Cytogenetic analysis on peripheral blood lymphocytes in blood malignancies and some solid cancers

الملخص EN

This study includes the cytogenetic analysis of the peripheral white blood cells for patients with blood malignancies & some solid tumors.

Eighty one blood samples were studies, 17 samples (20 .9%) showed non-dividing cells, while 36 samples (44.5%) have apparently normal karyotyping & 28 samples (34.6%) showed chromosomal abnormalities either structural aberration or numerical aberrations.

Metaphases of blood malignancies showed Philadelphia chromosome while the metaphases o solid tumors (lung cancer, bladder cancer, breast cancer & cervical cancer) were showed numerical & structural chromosomal abnormalities (include polyploidy, monosomy-16, trisomy + 5, Del 9q, Del llq & chromosomal marker The results showed a high frequency of chronic myeloid leukemia (CML), breast cancer & cervical cancer in (30- 39 ) & (40- 49) years old leukemia age groups.