Can continuous venovenous hemofiltration prevent contrast-agent induced nephropathy in patients with advanced chronic kidney disease after coronary angiography?

الملخص EN

To determine whether contrast induced nephropathy (CIN) post coronary angiography procedure can be prevented in chronic kidney disease (CKD) patients by continuous venovenous hemofiltration (CVVH), we evaluated 98 CKD patients [52 (53.1%) were males, the mean age was 60.7 ± 11.0 years] who underwent coronary angiography from January 2004 to December 2006.

Serum creatinine (Cr) before the procedure was 411 ± 79.9 μmol/L and creatinine clearance (Cr Cl) was 18.04 ± 4.26 mL/min.

All patients underwent post procedure CVVH for 21.34 ± 2.12 hours.

The mean time interval between the procedure and the start of CVVH was 44.3 ± 18.8 min.

The mean serum Cr at discharge was 403 ± 88.4 μmol/L (Cr Cl 18.5 ± 4.61 mL/min) and was 423 ± 88.9 μmol/L (Cr Cl17.6 ± 4.27 mL/min) 15 days after the procedure.

One patient (1.02%) developed worsening of renal functions that required repeated CVVH during hospitalization and ended up on regular hemodialysis.

There was no in-hospital mortality.

We conclude that CVVH is effective in preventing CIN after coronary angiography in CKD patients.