Evaluation of the role of leptin levels in the differential diagnosis of benign and malignant ascites
المؤلفون المشاركون
Shawqi, Amal
Mahmud, Ghadah
al-Khidr, Inas
Yusri, Inji
Mahmud, Halah
المصدر
Egyptian Journal of Applied Endocrinology
العدد
المجلد 26، العدد 1-2 (31 يوليو/تموز 2008)، ص ص. 207-219، 13ص.
الناشر
الجمعية المصرية للغدد الصماء التطبيقية
تاريخ النشر
2008-07-31
دولة النشر
مصر
عدد الصفحات
13
التخصصات الرئيسية
الموضوعات
الملخص EN
Background and aim: Leptin serum levels varies considerably among individuals.
It has been found to be reduced in malnourished patients and low or in the normal range in patients suffering from chronic illness.
The aim of the present study was to evaluate the role of leptin levels in the differential diagnosis of benign and malignant ascites.
Methods: serum and ascitic fluid leptin levels were measured in 40 patients with ascites (20) with different causes of malignant ascitis, (20) with liver cirrhosis.
Control serum samples were obtained from 15 healthy subjects.
Body mass index (BMI) and percentage of body fat (BF%) and skin fold measurements were calculated for all patients and control group.
Routine laboratory investigation, tumor markers, radiological studies, ascitic fluid cytology, culture and biochemical values were used for diagnosis of patients. Results: serum leptin levels were significantly elevated in cirrhotic patients compared to patients with malignancies and control subjects (P< 0.01) with significantly higher levels in females than males in all subjects.
Ascitic fluid leptin levels were significantly decreased in patients with malignancies compared to cirrhotic patients(P< 0.01).
Highly significant positive correlation existed between serum leptin levels and BF% ( p‹ 0.01) among cirrhotic group.
Highly significant positive correlation existed between serum leptin levels and skin fold thickness (p‹ 0.01) among malignant group. Conclusion: serum and ascitic fluid Leptin levels of malignant patients were significantly lower than cirrhotic patients.
This suggests a role of leptin in differential diagnosis of benign and malignant ascites.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Shawqi, Amal& Mahmud, Ghadah& al-Khidr, Inas& Yusri, Inji& Mahmud, Halah. 2008. Evaluation of the role of leptin levels in the differential diagnosis of benign and malignant ascites. Egyptian Journal of Applied Endocrinology،Vol. 26, no. 1-2, pp.207-219.
https://search.emarefa.net/detail/BIM-248809
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
al-Khidr, Inas…[et al.]. Evaluation of the role of leptin levels in the differential diagnosis of benign and malignant ascites. Egyptian Journal of Applied Endocrinology Vol. 26, no. 1-2 (Jul. 2008), pp.207-219.
https://search.emarefa.net/detail/BIM-248809
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Shawqi, Amal& Mahmud, Ghadah& al-Khidr, Inas& Yusri, Inji& Mahmud, Halah. Evaluation of the role of leptin levels in the differential diagnosis of benign and malignant ascites. Egyptian Journal of Applied Endocrinology. 2008. Vol. 26, no. 1-2, pp.207-219.
https://search.emarefa.net/detail/BIM-248809
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 214-215.
رقم السجل
BIM-248809
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر