AY2 subunit of Y-aminobutyric acid type a receptor (GABRG2) gene polymorphism in children with febrile seizures
المؤلفون المشاركون
Emama, Ihab K.
Alya, Rasha H.
Muhammad, Rasha M.
Kamel, Ahmad S.
المصدر
Egyptian Pediatric Association Gazette
العدد
المجلد 57، العدد 3 (31 يوليو/تموز 2009)، ص ص. 5-16، 12ص.
الناشر
تاريخ النشر
2009-07-31
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الموضوعات
الملخص EN
Background : the y-Amino butyric Acid Receptor (GABR) is the predominant ligand-gated CI-ion channel conferring fast inhibitory synaptic transmission in the CNS, hence an abnormality of gamma-amino butyric acid (GABA)-ergo neurotransmission has been suggested as an etiologic factor in epileptogenesis.
Missense mutations in the y2 subunit of y-Amino butyric Acid Type A Receptor (GABRG2) gene, which encodes the y2 subunit of central nervous GABAA receptors, have been described with familial epilepsies.
It is not known, however, whether polymorphisms in those genes also contribute to the pathogenesis of FS.
Aims: to investigate whether polymorphisms in GABRG2 also contribute to the pathogenesis of Febrile Seizures (FS).
Methods : A total of 42 children with FSs and 50 normal control subjects were included in the study.
Polymerase chain reaction was used to identify the C / T polymorphism of the GABRG2 gene on chromosome 5q33.
Genotyping and allelic frequencies for gene polymorphism in both groups were compared.
Results : the number individuals with a homozygous GABRG2 (SNP211037)-C genotype and the C- allele frequency were significantly higher (p<0.05 and p<0.01 respectively), in patients with FSs compared to healthy controls.
Furthermore, the number of homozygous GABRG2 (SNP211037)-C genotype and the C-allele frequency were significantly higher in patients with positive family history of FSs compared to patients with negative family history.
Conclusion : this study demonstrated an association between the GABRG2 gene and FSs.
It also suggests that the GABRG2 gene or a closely linked gene might be one of the susceptibility factors for FSs.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Emama, Ihab K.& Alya, Rasha H.& Muhammad, Rasha M.& Kamel, Ahmad S.. 2009. AY2 subunit of Y-aminobutyric acid type a receptor (GABRG2) gene polymorphism in children with febrile seizures. Egyptian Pediatric Association Gazette،Vol. 57, no. 3, pp.5-16.
https://search.emarefa.net/detail/BIM-249163
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Alya, Rasha H.…[et al.]. AY2 subunit of Y-aminobutyric acid type a receptor (GABRG2) gene polymorphism in children with febrile seizures. Egyptian Pediatric Association Gazette Vol. 57, no. 3 (Jul. 2009), pp.5-16.
https://search.emarefa.net/detail/BIM-249163
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Emama, Ihab K.& Alya, Rasha H.& Muhammad, Rasha M.& Kamel, Ahmad S.. AY2 subunit of Y-aminobutyric acid type a receptor (GABRG2) gene polymorphism in children with febrile seizures. Egyptian Pediatric Association Gazette. 2009. Vol. 57, no. 3, pp.5-16.
https://search.emarefa.net/detail/BIM-249163
نوع البيانات
مقالات
لغة النص
الإنجليزية
رقم السجل
BIM-249163
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر