QSAR studies on anti-apoptotic Bcl-2 protein inhibitors

الملخص EN

QSAR studies on a series of inhibitors for anti-apoptotic Bcl-2 proteins based on BHI-1 were performed the activities are found to correlate well with some topological parameters and ste-ric parameters.

The results are critically discussed on the basis of regression data, Pogliani factor Q and cross validation technique.

The results are found to be useful in discussing the mechanism of drug-receptor interaction.