Synthesis and properties of novel alkoxy- and phenoxyalkyl ethers of secondary and tertiary ethynylpiperidin-4-ols possessing unusual analgesic, anti-bacterial, anti-spasmotic, and anti-allergic properties as well as low toxicity
المؤلفون المشاركون
Yu, Valentina K.
Kabdraissova, Aissulu Zh.
Praliyev, Kaldybay D.
Shin, Svetlana N.
Berlin, K. Darrell
المصدر
Journal of Saudi Chemical Society
العدد
المجلد 13، العدد 2 (31 أغسطس/آب 2009)، ص ص. 209-217، 9ص.
الناشر
تاريخ النشر
2009-08-31
دولة النشر
السعودية
عدد الصفحات
9
التخصصات الرئيسية
الموضوعات
الملخص EN
Methodology was developed to obtain a series of unusual alkoxy-and phenoxyalkyl ethers of secondary and tertiary ethynylpiperidin-4-ols representative examples of which were evaluated for analgesic, anti-bacterial, anti-spasmodic, and anti-allergic activity.
Twenty-two new compounds were prepared and identified by elemental and spectra analyses.
Etherification of 4-hydroxypiperidin-4-ols was accomplished via Williamson ether-type syntheses in dry DMF.
Side reactions of the bromides used appeared to involve complex processes with DMF under a variety of conditions employed which led to modest yields of products.
Since all target molecules were oils at room temperature, conversions to P-cyclodextrins were accomplished and served as vehicles for pharmacological screening.
Several ethyl-substituted agents displayed deep analgesic activity in the "tail flick" model although some alkoxy- and phenoxy ethers from secondary alcohols were less effective as analgesics (Table 1).
Interestingly, LD50 values for the agents.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Yu, Valentina K.& Kabdraissova, Aissulu Zh.& Praliyev, Kaldybay D.& Shin, Svetlana N.& Berlin, K. Darrell. 2009. Synthesis and properties of novel alkoxy- and phenoxyalkyl ethers of secondary and tertiary ethynylpiperidin-4-ols possessing unusual analgesic, anti-bacterial, anti-spasmotic, and anti-allergic properties as well as low toxicity. Journal of Saudi Chemical Society،Vol. 13, no. 2, pp.209-217.
https://search.emarefa.net/detail/BIM-250899
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Yu, Valentina K.…[et al.]. Synthesis and properties of novel alkoxy- and phenoxyalkyl ethers of secondary and tertiary ethynylpiperidin-4-ols possessing unusual analgesic, anti-bacterial, anti-spasmotic, and anti-allergic properties as well as low toxicity. Journal of Saudi Chemical Society (Aug. 2009), pp.209-217.
https://search.emarefa.net/detail/BIM-250899
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Yu, Valentina K.& Kabdraissova, Aissulu Zh.& Praliyev, Kaldybay D.& Shin, Svetlana N.& Berlin, K. Darrell. Synthesis and properties of novel alkoxy- and phenoxyalkyl ethers of secondary and tertiary ethynylpiperidin-4-ols possessing unusual analgesic, anti-bacterial, anti-spasmotic, and anti-allergic properties as well as low toxicity. Journal of Saudi Chemical Society. 2009. Vol. 13, no. 2, pp.209-217.
https://search.emarefa.net/detail/BIM-250899
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 217
رقم السجل
BIM-250899
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر