Distribution of hepatitis c virus genotypes in iranian patients with congenital bleeding disorders
المؤلفون المشاركون
Keshvari, M.
Alavian, S. M.
Behnava, B.
Miri, S. M.
Elizee, P. Karimi
Tabatabaei, S. V.
Kafi-Abad, S. Amini
Abolghasemi, H.
Lankarani, K. B.
المصدر
Iranian Red Crescent Medical Journal
العدد
المجلد 12، العدد 6 (30 نوفمبر/تشرين الثاني 2010)، ص ص. 608-614، 7ص.
الناشر
تاريخ النشر
2010-11-30
دولة النشر
الإمارات العربية المتحدة
عدد الصفحات
7
التخصصات الرئيسية
الموضوعات
الملخص EN
Background : chronic hepatitis C virus (HCV) infection is the major cause of liver disease related morbidity and mortality in hemophilic patients who needs regular blood product administration.
Although genotype of infecting HCV is one of the prime predictors of response to antiviral therapy however, its distribution in hemophilic patients is still unclear and just few studies with low sample sizes have investigated this issue.
Therefore, in this study, we aimed to identify this distribution in 367 Iranian hemophilic patients.
Methods : blood samples were received from 367 hemophilic patients with chronic hepatitis C detected during a nationwide screening program who referred to our center for therapeutic measures.
HCV RNA viral load was detected using Ampliform test (Version 2).
Genotyping was performed by genotype specific primers.
Results : HCV genotype distribution was 1a in 58%, 3a in 18.5 %, 1b in 14.7 %, 4 in 1.1%, 2 in 0.8% and mixed in .%62and finally 0.5% of isolates were non-table.
Serum liver enzymes were not associated with HCV viral load and genotypes.
Patients with severe bleeding tendency had significantly lower serum liver enzymes than those with a mild bleeding tendency.
Conclusion : genotype 1a followed by 3a and 1b were the most frequently detected HCV genotypes in Iranian hemophilic patients and there was no association between splenomegaly and viral markers and liver enzymes in these patients.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Keshvari, M.& Alavian, S. M.& Behnava, B.& Miri, S. M.& Elizee, P. Karimi& Tabatabaei, S. V.…[et al.]. 2010. Distribution of hepatitis c virus genotypes in iranian patients with congenital bleeding disorders. Iranian Red Crescent Medical Journal،Vol. 12, no. 6, pp.608-614.
https://search.emarefa.net/detail/BIM-252155
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Keshvari, M.…[et al.]. Distribution of hepatitis c virus genotypes in iranian patients with congenital bleeding disorders. Iranian Red Crescent Medical Journal Vol. 12, no. 6 (Nov. 2010), pp.608-614.
https://search.emarefa.net/detail/BIM-252155
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Keshvari, M.& Alavian, S. M.& Behnava, B.& Miri, S. M.& Elizee, P. Karimi& Tabatabaei, S. V.…[et al.]. Distribution of hepatitis c virus genotypes in iranian patients with congenital bleeding disorders. Iranian Red Crescent Medical Journal. 2010. Vol. 12, no. 6, pp.608-614.
https://search.emarefa.net/detail/BIM-252155
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 613-614
رقم السجل
BIM-252155
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر