Comparative study between chop-like chemotherapy plus rituximab versus chop-like chemotherapy alone in young patients with good prognosis diffuse large-B-cell lymphoma
المؤلفون المشاركون
Ali, Inas Muhammad
Zaki, Sameh
Abd al-Karim, Yasir
المصدر
Journal of the Medical Research Institute
العدد
المجلد 29، العدد 2 (30 يونيو/حزيران 2008)، ص ص. 124-131، 8ص.
الناشر
جامعة الإسكندرية معهد البحوث الطبية
تاريخ النشر
2008-06-30
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الموضوعات
الملخص EN
Background :The role of rituximab in combination with different CHOP like chemotherapy regimens in young patients with good prognosis diffuse large B cell lymphoma remains to be defined.
Aim : We aimed to compare CHOP like chemotherapy and rituximab with CHOP like chemotherapy alone in patients with diffuse large B cell lymphoma who had no risk factor or one risk factor regarding response, progression free survival and overall survival as well as toxicity.
Materials and Methods: Eighty patients aged 18-60 years with histologically confirmed diffuse large B cell lymphoma who had no risk factor or one risk factor according to the age adjusted international prognostic index were treated either with: group A treated CHOP chemotherapy alone, group B treated with CHOP E (CHOP plus Etoposide), group C treated with CHOP-R (CHOP plus rituximab), group D treated with CHOP-E-R (CHOP plus Etoposid and retuximab).
Evaluation of response progression free survival overall survival as well as Results .
: Patients treated with CHOP rituximab (CHOP-R) had better response (86%) than those treated with CHOP alone or CHOP plus etoposide (CHOP E) (83%, 85%) respectively but the difference between the groups was not statistically significant.
There was no statistical significant difference between the studied groups regarding over all survival 92% in group B, 93% in group C and 91% in group D.
Conclusions: Rituximab when added to six cycles of CHOP is an effective treatment for young good prognosis diffuse large B cell lymphoma however etoposide added to six cycles CHOP is also an effective treatment for young good prong
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Ali, Inas Muhammad& Zaki, Sameh& Abd al-Karim, Yasir. 2008. Comparative study between chop-like chemotherapy plus rituximab versus chop-like chemotherapy alone in young patients with good prognosis diffuse large-B-cell lymphoma. Journal of the Medical Research Institute،Vol. 29, no. 2, pp.124-131.
https://search.emarefa.net/detail/BIM-258273
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Ali, Inas Muhammad…[et al.]. Comparative study between chop-like chemotherapy plus rituximab versus chop-like chemotherapy alone in young patients with good prognosis diffuse large-B-cell lymphoma. Journal of the Medical Research Institute Vol. 29, no. 2 (2008), pp.124-131.
https://search.emarefa.net/detail/BIM-258273
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Ali, Inas Muhammad& Zaki, Sameh& Abd al-Karim, Yasir. Comparative study between chop-like chemotherapy plus rituximab versus chop-like chemotherapy alone in young patients with good prognosis diffuse large-B-cell lymphoma. Journal of the Medical Research Institute. 2008. Vol. 29, no. 2, pp.124-131.
https://search.emarefa.net/detail/BIM-258273
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 130-131
رقم السجل
BIM-258273
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر