Evaluation of N-terminal Pro-Brain natriuretic peptide as a diagnostic marker in acute heart failure
المؤلفون المشاركون
Sudrak, Mona S.
Zakariyya, Nirmin H.
Lotfy, Mohamed I.
al-Rashidy, Dina
المصدر
Journal of the Medical Research Institute
العدد
المجلد 29، العدد 2 (30 يونيو/حزيران 2008)، ص ص. 140-149، 10ص.
الناشر
جامعة الإسكندرية معهد البحوث الطبية
تاريخ النشر
2008-06-30
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الموضوعات
الملخص EN
Background : The rapid and accurate differentiation of heart failure from other causes of dyspnea remains a clinical challenge in the emergency setting.
The present work aimed at evaluating the role of N-terminal probrain natriuretic peptide (NTproBNP) as a marker for diagnosis or ruling out of acute ventricular heart failure Patients and methods : forty male patients presented with symptoms and signs of acute heart failure were recruited.
They were in their first presentation or were acute cases on top of chronic heart failure.
Blood samples were taken twice from each patient; once on admission day and five days later after receiving treatment.
Twenty healthy matched adult males were recruited as controls.
NTproBNP was quantitatively assayed using competitive enzyme linked immunosorbant assay.
Results : The median level of NTproBNP showed a statistically significant difference between the patients whether before or after treatment and the controls P (<0.001) and between the two subgroups of patients before and after treatment where the median level of NT-proBNP was markedly decreased in patients after treatment (<0.001).
The median level of NTproBNP showed a statistically significant difference between the functional classes of heart failure as categorized by echocardiogram both before and after treatment; where cases with normal echocardiography findings showed marked reduction with statistical significant difference P (<0.001) while cases with abnormal echocardiography findings showed more marked reduction in level with statistically significant difference P (<0.001) .The receiver operating characteristic (ROC) curve at a cut off level of 147.7 fmol /ml of NTproBNP before treatment showed a sensitivity of 100% and a specificity of 80%;Positive predictive value of 93.8; negative predictive value of 100 ; accuracy of 95% with area under the curve (AUC)of 5, while the level of NTproBNP after treatment at the same cut off level showed marked reduction in sensitivity of 46.7% and a specificity was 80% Positive predictive value of 87.5; negative predictive value of 87.5 ; accuracy of 55 % with area under the curve (AUC) of 2.3.
Conclusions : Measurement of NTproBNP in subjects presented with dyspnea and other signs of heart failure to the emergency department; may provide a reliable diagnostic laboratory tool for diagnosis of heart failure.
The number of echo needed and the cost of screening can hence be reduced.
NTproBNP marker could be used in acute heart failure cases when firsly presented but not previously treated.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Sudrak, Mona S.& Zakariyya, Nirmin H.& Lotfy, Mohamed I.& al-Rashidy, Dina. 2008. Evaluation of N-terminal Pro-Brain natriuretic peptide as a diagnostic marker in acute heart failure. Journal of the Medical Research Institute،Vol. 29, no. 2, pp.140-149.
https://search.emarefa.net/detail/BIM-258308
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Lotfy, Mohamed I.…[et al.]. Evaluation of N-terminal Pro-Brain natriuretic peptide as a diagnostic marker in acute heart failure. Journal of the Medical Research Institute Vol. 29, no. 2 (2008), pp.140-149.
https://search.emarefa.net/detail/BIM-258308
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Sudrak, Mona S.& Zakariyya, Nirmin H.& Lotfy, Mohamed I.& al-Rashidy, Dina. Evaluation of N-terminal Pro-Brain natriuretic peptide as a diagnostic marker in acute heart failure. Journal of the Medical Research Institute. 2008. Vol. 29, no. 2, pp.140-149.
https://search.emarefa.net/detail/BIM-258308
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 147-149
رقم السجل
BIM-258308
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر