Role of omeprazole as an antifungal agent

الملخص EN

The antifungal activity of various, concentrations of omeprazole (0.1mg / ml 0,25mg / ml, 0.5mg / ml, 1mg / ml, 2.5mg / ml, 5mg / ml, 10mg / ml, and 20mg / ml) were studied in different pH media (5 and 7) against Aspergillus niger, and Trichophyton urbrum.

The laboratory results showed the inhibitory effect of omeprazole against Aspergillus niger at pH 7 and starting from concentration 10mg / ml, and against Trichophyton urbrum starting from 1mg / ml.

While its antifungal activity in a medium with pH 5 was extended to reach the lower concentrations 0.25mg / ml against selected fungi.

Accordingly, omeprazole is pH dependent.It seems that omeprazole changed cell membrane potential of selected fungal species which led to depolarization of cell membrane as a result of inhibition of the proton pump mechanism.

This made the fungal cell not willing to uptake chemicals needed for living.

Keywords: omeprazole, proton pump inhibitor.

antifungal agent, Aspergillus niger, and Trichophyton urbrum.