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Gene polymorphisms of TNF-α and IL-10 related to rheumatic heart disease
المؤلفون المشاركون
Tawfiq, Inas
Abd al-Salam, Manal
Abd al-Karim, Arwa
Yusri, Muna
المصدر
The Egyptian Journal of Medical Human Genetics
العدد
المجلد 11، العدد 1 (31 مايو/أيار 2010)، ص ص. 33-45، 13ص.
الناشر
الجمعية المصرية للأمراض الوراثية
تاريخ النشر
2010-05-31
دولة النشر
مصر
عدد الصفحات
13
التخصصات الرئيسية
الموضوعات
الملخص EN
Background : Rheumatic fever (RF) is inherited as a single recessive gene.
Several genes are Likely to predispose an individual to develop rheumatic fever and rheumatic heart disease (RHD).
Polymorphisms of TNF-α gene were associated with susceptibility to develop RF.T cells from all rheumatic fever patients produce significant amounts of TNF-α in response to steptococcal peptides with the highest production attained by the chronic rheumatic heart disease patients,and IL-10 expression was characterized in heart tissue of RHD patients by immuno-histochemistry.
Objectives : To test the relation of RHD and gene polymorphisms of proinflammatory cytokines TNF-α gene at position -308 and anti–inflammatory IL-10 gene at position -1082.
Subjects and Methods : This study included 20 children with chronic rheumatic heart disease (group A) and 10 healthy children as a control group (Group B).
Patients group was classified into patients with single and multiple valvular lesions, both of them were classified according to the severity by Echocardiography into : Group I: mild valvular lesion (n=7) Group II: Moderate lesion (n=4) Group III: severe lesion (n=9) Real time PCR was done for both TNF-α at-308 and IL-10 at position – 1082.
Results : All cases showed significant higher frequency of TNF-α homozygous genotype G/G compared to control group (p <0.05,OR,11).
Cases with severe valvular lesions showed increased frequency of homozygous genotype G/G and increased frequency of IL-10 genotype G/A in cases compared to control group (p ≤0.05,OR 13).
There was no statistically significant difference in frequency of IL-10 genotypes among cases and control groups regarding to severity of valvular lesions.
Composite genotypes (TNF-α G/G,IL-10 G/A) were higher in cases compared to control group (P ≤ 0.01), while composite genotypes (TNF-α G/A,IL -10 G/G) were higher in control group compared to cases groups.
Conclusions : Susceptibility to RHD is associated with cytokine gene polymorphisms of TNF-α homozygous genotype G/G at-308 and IL-10 G/A at 1082.
Composite genotypes (TNF-α G/G,IL-10 G/A) had high risk for RHD, while composite genotypes (TNF-α G/A,IL-10 G/G) may be protective genotypes.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Tawfiq, Inas& Abd al-Salam, Manal& Abd al-Karim, Arwa& Yusri, Muna. 2010. Gene polymorphisms of TNF-α and IL-10 related to rheumatic heart disease. The Egyptian Journal of Medical Human Genetics،Vol. 11, no. 1, pp.33-45.
https://search.emarefa.net/detail/BIM-262018
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Tawfiq, Inas…[et al.]. Gene polymorphisms of TNF-α and IL-10 related to rheumatic heart disease. The Egyptian Journal of Medical Human Genetics Vol. 11, no. 1 (May. 2010), pp.33-45.
https://search.emarefa.net/detail/BIM-262018
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Tawfiq, Inas& Abd al-Salam, Manal& Abd al-Karim, Arwa& Yusri, Muna. Gene polymorphisms of TNF-α and IL-10 related to rheumatic heart disease. The Egyptian Journal of Medical Human Genetics. 2010. Vol. 11, no. 1, pp.33-45.
https://search.emarefa.net/detail/BIM-262018
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 43-45
رقم السجل
BIM-262018
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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