Gene polymorphisms of TNF-α and IL-10 related to rheumatic heart disease
المؤلفون المشاركون
Tawfiq, Inas
Abd al-Salam, Manal
Abd al-Karim, Arwa
Yusri, Muna
المصدر
The Egyptian Journal of Medical Human Genetics
العدد
المجلد 11، العدد 1 (31 مايو/أيار 2010)، ص ص. 33-45، 13ص.
الناشر
الجمعية المصرية للأمراض الوراثية
تاريخ النشر
2010-05-31
دولة النشر
مصر
عدد الصفحات
13
التخصصات الرئيسية
الموضوعات
الملخص EN
Background : Rheumatic fever (RF) is inherited as a single recessive gene.
Several genes are Likely to predispose an individual to develop rheumatic fever and rheumatic heart disease (RHD).
Polymorphisms of TNF-α gene were associated with susceptibility to develop RF.T cells from all rheumatic fever patients produce significant amounts of TNF-α in response to steptococcal peptides with the highest production attained by the chronic rheumatic heart disease patients,and IL-10 expression was characterized in heart tissue of RHD patients by immuno-histochemistry.
Objectives : To test the relation of RHD and gene polymorphisms of proinflammatory cytokines TNF-α gene at position -308 and anti–inflammatory IL-10 gene at position -1082.
Subjects and Methods : This study included 20 children with chronic rheumatic heart disease (group A) and 10 healthy children as a control group (Group B).
Patients group was classified into patients with single and multiple valvular lesions, both of them were classified according to the severity by Echocardiography into : Group I: mild valvular lesion (n=7) Group II: Moderate lesion (n=4) Group III: severe lesion (n=9) Real time PCR was done for both TNF-α at-308 and IL-10 at position – 1082.
Results : All cases showed significant higher frequency of TNF-α homozygous genotype G/G compared to control group (p <0.05,OR,11).
Cases with severe valvular lesions showed increased frequency of homozygous genotype G/G and increased frequency of IL-10 genotype G/A in cases compared to control group (p ≤0.05,OR 13).
There was no statistically significant difference in frequency of IL-10 genotypes among cases and control groups regarding to severity of valvular lesions.
Composite genotypes (TNF-α G/G,IL-10 G/A) were higher in cases compared to control group (P ≤ 0.01), while composite genotypes (TNF-α G/A,IL -10 G/G) were higher in control group compared to cases groups.
Conclusions : Susceptibility to RHD is associated with cytokine gene polymorphisms of TNF-α homozygous genotype G/G at-308 and IL-10 G/A at 1082.
Composite genotypes (TNF-α G/G,IL-10 G/A) had high risk for RHD, while composite genotypes (TNF-α G/A,IL-10 G/G) may be protective genotypes.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Tawfiq, Inas& Abd al-Salam, Manal& Abd al-Karim, Arwa& Yusri, Muna. 2010. Gene polymorphisms of TNF-α and IL-10 related to rheumatic heart disease. The Egyptian Journal of Medical Human Genetics،Vol. 11, no. 1, pp.33-45.
https://search.emarefa.net/detail/BIM-262018
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Tawfiq, Inas…[et al.]. Gene polymorphisms of TNF-α and IL-10 related to rheumatic heart disease. The Egyptian Journal of Medical Human Genetics Vol. 11, no. 1 (May. 2010), pp.33-45.
https://search.emarefa.net/detail/BIM-262018
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Tawfiq, Inas& Abd al-Salam, Manal& Abd al-Karim, Arwa& Yusri, Muna. Gene polymorphisms of TNF-α and IL-10 related to rheumatic heart disease. The Egyptian Journal of Medical Human Genetics. 2010. Vol. 11, no. 1, pp.33-45.
https://search.emarefa.net/detail/BIM-262018
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 43-45
رقم السجل
BIM-262018
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر