CD4+ T cell response in HIV-positive women initiating highly active anti-retroviral therapy (HAART) at general gospital, Kabba, Kogi State, Nigeria
المؤلفون المشاركون
Sule, Waidi Folorunso
Olumorin, J. K.
المصدر
Jordan Journal of Biological Sciences
العدد
المجلد 3، العدد 2 (31 مارس/آذار 2010)، ص ص. 41-50، 10ص.
الناشر
الجامعة الهاشمية عمادة البحث العلمي و الدراسات العليا
تاريخ النشر
2010-03-31
دولة النشر
الأردن
عدد الصفحات
10
التخصصات الرئيسية
الموضوعات
الملخص EN
Reportedly, HIV-infected patients on HAART exhibited accelerated increase in the first three months.
We therefore tested a hypothesis that there is no difference between 3 month follow-up and baseline CD4 counts of HIV-positive women initiating Stavudine, Lamivudine and Nevirapine at General Hospital, Kabba, Kogi State, Nigeria.
As a prospective study, 100 consenting HIV-positive, HAART-naïve women aged 17-45 years were studied.
Two blood samples were aseptically obtained by venipuncture from each woman before and after 3 months on HAART and assessed for pre– and post–therapeutic CD4 counts using automated FACSCount® System.
Pertinent data of participants were obtained using questionnaire forms.
For the purpose of comparison, the women were grouped into pre-therapeutic CD4 count of < 200; 200-349 and ≥ 350 cells / μl groups.
SPSS 15.0 was used for the statistical analyses.
The mean baseline and follow-up CD4 counts were respectively 320.03 cells / μl and 620.92 cells / μl (n =100), the latter was significantly (P = 0.001) higher than the former.
Unlike the mean follow-up CD4 count of the women in the ≥ 350 cells / μl group, mean follow-up CD4 counts of those in the < 200 and 200-349 CD4 cells / μl groups were significant (P = 0.001) higher than their respective mean baseline values.
The 74 women who responded “adherent” to HAART had significantly (P = 0.001) higher mean follow-up CD4 count contrary to that of the remaining 26 “non-adherent” women who exclusively belonged to the ≥ 350 CD4 cells / μl group.
The women who responded “yes” and “no” to having diabetes/hepatitis were comparable (P = 0.62) in their mean follow-up CD4 counts.
We concluded that 75% of the HIV-positive women had significant increase in CD4 count, hence they had short-term immunologic benefit; and that rather than the pre-therapeutic CD4 count of ≥ 350 cells / μl or having diabetes / hepatitis, it was “non-adherence” to HAART that apparently accounted for lack of therapeutic benefit among the 10 women who had < 349 CD4 cells / μl after 3 months on HAART.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Sule, Waidi Folorunso& Olumorin, J. K.. 2010. CD4+ T cell response in HIV-positive women initiating highly active anti-retroviral therapy (HAART) at general gospital, Kabba, Kogi State, Nigeria. Jordan Journal of Biological Sciences،Vol. 3, no. 2, pp.41-50.
https://search.emarefa.net/detail/BIM-264604
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Sule, Waidi Folorunso& Olumorin, J. K.. CD4+ T cell response in HIV-positive women initiating highly active anti-retroviral therapy (HAART) at general gospital, Kabba, Kogi State, Nigeria. Jordan Journal of Biological Sciences Vol. 3, no. 2 (Mar. 2010), pp.41-50.
https://search.emarefa.net/detail/BIM-264604
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Sule, Waidi Folorunso& Olumorin, J. K.. CD4+ T cell response in HIV-positive women initiating highly active anti-retroviral therapy (HAART) at general gospital, Kabba, Kogi State, Nigeria. Jordan Journal of Biological Sciences. 2010. Vol. 3, no. 2, pp.41-50.
https://search.emarefa.net/detail/BIM-264604
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 48-50
رقم السجل
BIM-264604
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر