Relationship of sICAM-1 and sE-selectin to obesity measures in an Egyptian female sample

الملخص EN

Objectives: To evaluate circulating levels of sICAM-1, and sE-Selectin as indices of endothelial activation in a sample of obese young Egyptian females. Methodology: Thirty obese and 30 non-obese premenopausal females were included in the study.

They were subjected to complete clinical examination, and measurement of body mass index (BMI) & waist/ hip ratio (W/H ratio).

Laboratory measurements included serum cholesterol (TC), serum LDL & HDL cholesterol, serum triglycerides (TG) and body fat %.

Serum sICAM-1 and sE-Selectin concentrations were measured with ELISA technique.

The treatment program included balanced low calorie food regimen and daily exercise therapy for 45 -60 minutes at the intensity of 70-85% of maximum heart rate.

Obese patients were reassessed after 3 months.

Results: Obese females had significantly higher BMI, TC, LDL cholesterol, TG, body fat % and plasma levels of sE-Selectin and sICAM-1.

HDL cholesterol was significantly lower in the obese group.

Highly significant correlations were found between sE-Selectin and BMI, W/H ratio, TC, LDL cholesterol and body fat %.

There was a significant correlation with TG, while sICAM-1 significantly correlated with BMI, TC and LDL cholesterol.

A negative significant correlation was found between HDL cholesterol and CAMs.

After treatment program, serum levels of sE-Selectin, sICAM-1 were significantly lowered with significant reductions in BMI, TC, LDL cholesterol, and TG and body fat %.

Conclusions: Circulating levels of sE-Selectin and sICAM-1are related to anthropometric and metabolic measures of obesity.

sE-Selectin showed the strongest association with central obesity.

Combined weight reduction, physical activity resulted in decrease in sE-Selectin and sICAM-1 levels.