Serum calcium, inorganic phosphate, uric acid, copper, zinc and magnesium in Osteoarthritis Patients

الملخص EN

This study aimed to, know, the, effect of ...serum calcium(Ca), inorganic phosphate(P), uric acid (UA), copper(Cu), zinc(Zn) and magnesium(Mg) on osteoarthritic (OA) patients who are, having pure OA of knee & those having diffuse OA (knee and spine), and to clarify the relationship of those parameters with severity of symptoms and radiological findings.

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, This is a prospective case control ;study, conducted at Basrah province through of a period of 9 months from-October 2001^ .td Juries 2002,vduring which'.100 patients With different types of OA were admitted.

To the Orthopedics Clinic 6f Basrah GenerarHospital.

Their age ranged from 40 to 68 years olds (24 males arid 76 females), were allocated into 3 groups (mild, moderate and sever OA) according to.

their symptorfis and radiological findings.

Cn the other.

Hand 80 apparently heath subjects (23 males and 57 females).

Their ages ranged from 40-70 years old were participated as a control group.

Venous blood samples were collected from each subjects and patients participated in this study for measurements CA, P, UA ,Cu, Zn and.Mg by using standard methods.

Among two age groups arid in.female patients serum Ca, level was.

Highly significantly lowered (p < 0.01) in patients with moderate OA of knee as compared with mild OA patients.

Serum uric acid was significantly increased(p< 0.05) in patients having mild OA of knee as compared with mild OA of (knee and spine) at age group £ 55 years, the same results was observed in male patients as compared to the females group.

Serum Cu and P levels were non¬significant^ altered (p > 0.05) in two types of OA among different age and sex groups.

Serum Zn levels was significantly lowered (P>0.05) in patients with moderate and mild OA of knee and in sever and moderate OA of knee and combined for serum Mg levels among different age and sex groups.

On the basis of this study, it can be concluded that incidence of moderate OA were high and represent 58% of total numbers of patient studied who were at higher risk of significantly decrease in the concentration of calcium, zinc and magnesium.