Cartilage oligomeric matrix protein (COMP) in arthritis : is it a valuable serum marker of inflammation and bone mineral density changes?
المؤلفون المشاركون
Husayn, Ula Ali
al-Shahawy, Iman al-Dasuqi
Umran, Ala A.
Jab Allah, Ahmad Muhammad
Najib, Ghadah Sanad
Ali, Manal Abd
Jawhar, Ghadah Kamal
المصدر
Egyptian Rheumatology and Rehabilitation
العدد
المجلد 35، العدد 1 (31 يناير/كانون الثاني 2008)8ص.
الناشر
الجمعية المصرية للروماتيزم و التأهيل
تاريخ النشر
2008-01-31
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الموضوعات
الملخص EN
Hypothesis : Cartilage Oligomeric Matrix Protein (COMP) is a non-collage nous glycoprotein, which occurs mainly in an articular cartilage.
This protein increases under the influence of cytokines and growth factors as a result of various diseases that cause damage to cartilage, fragments of it are released into synovial fluid and then into blood (serum COMP).
Objectives : To assess the value of serum COMP (sCOMP) as an inflammatory marker in Rheumatoid Arthritis (RA), Systemic Lupus Erythematosus (SLE), Osteoarthritis (OA) patients, and to find its correlation with disease activity & bone mineral density changes (BMD).
Methodology : This study was conducted on 100 subjects including ten healthy volunteers as group I, 30 RA patients (group II), 25 SLE patients (group III), and 35 patients with knee OA (group IV).
In addition to the physical examinations, activity was assessed in RA and SLE patients.
WOMAC index was also performed for OA patients.
Assessment of sCOMP level was determined, in addition to assessment of bone mineral density changes by DEXA.
Results : The mean values of sCOMP in RA, SLE and OA patients were 10.6 ± 3.8 U / l, 11.9 ± 3.1 U / l, and 10.9 ± 2.9 U / l respectively.
In the control group it was 5.9 ± 1.1 U / l.
Serum COMP level in RA patients was significantly higher in patients with DAS >3.7 (p<0.05) , and in patients with (ESR) value ≥ 40 mm / h compared with patients with ESR value < 40 mm / h (p < 0.05).
A high significant elevation of sCOMP level was obtained in SLE patients with hemoglobin (Hb) < 11.0 g /l, as well as those with ESR ≥ 40 mm / h (p < 0.01).
In addition, SLE patients with SLEDAI > 6 showed high significantly elevated sCOMP level than those with SLEDAI > 6 (p < 0.01).
In OA patients, the level of sCOMP was significantly elevated in those with BMD < -2.5 than those with BMD ≥-2.5.
High significant elevation was detected on comparing sCOMP level in either of group II, group III or group IV with group I (p < 0.01 for all).
In RA patients a significant positive correlation was detected between the sCOMP level and disease activity score (DAS), Hb, ESR (r = 0.42, 0.39, 0.37 respectively) (p < 0.05 for all).
In SLE patients a high significant negative correlation was found between the sCOMP level and Hb (r = -0.50, p < 0.01), and significant positive correlation was found between the sCOMP level and ESR (r = 0.40, p < 0.05).
In OA patients a significant positive correlation was found between the sCOMP level and WOMAC index (r = 0.39), and high significant negative correlation between the sCOMP level and T-score (r = -0.60, p>0.01).
Conclusions: Measurement of sCOMP is valuable for monitoring inflammation in both inflammatory e.g.
(SLE, RA) and degenerative joint diseases e.g.
(OA) we observed its correlations with activity parameters in RA and SLE.
More over OA patients had significant and high significant positive correlation of sCOMP with WOMAC index and the changes of bone mineral density (T-score) values respectively.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Najib, Ghadah Sanad& al-Shahawy, Iman al-Dasuqi& Ali, Manal Abd& Umran, Ala A.& Husayn, Ula Ali& Jab Allah, Ahmad Muhammad…[et al.]. 2008. Cartilage oligomeric matrix protein (COMP) in arthritis : is it a valuable serum marker of inflammation and bone mineral density changes?. Egyptian Rheumatology and Rehabilitation،Vol. 35, no. 1.
https://search.emarefa.net/detail/BIM-26609
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Najib, Ghadah Sanad…[et al.]. Cartilage oligomeric matrix protein (COMP) in arthritis : is it a valuable serum marker of inflammation and bone mineral density changes?. Egyptian Rheumatology and Rehabilitation Vol. 35, no. 1 (Jan. 2008).
https://search.emarefa.net/detail/BIM-26609
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Najib, Ghadah Sanad& al-Shahawy, Iman al-Dasuqi& Ali, Manal Abd& Umran, Ala A.& Husayn, Ula Ali& Jab Allah, Ahmad Muhammad…[et al.]. Cartilage oligomeric matrix protein (COMP) in arthritis : is it a valuable serum marker of inflammation and bone mineral density changes?. Egyptian Rheumatology and Rehabilitation. 2008. Vol. 35, no. 1.
https://search.emarefa.net/detail/BIM-26609
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references.
رقم السجل
BIM-26609
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر