New approach of ethyl substituted Isoquinoline-3-carboxylate synthesis

الملخص EN

The application of palladium catalysis for carbon-carbon bond formation is particularly attractive owing to the mild reaction conditions and high reaction yields.

The synthesis of ethyl1, 4-disubstitued isoquinoline-3-carboxylate derivatives was achieved in four steps utilizing readily available N-substituted phthalimide by employing Suzuki reaction as a key step.

In the Pd (0)-catalyzed cross coupling step, a regioselectivity was observed between triflate-enol ether and triflate-imino ether.

The present methodology can provide an expedient access to diversely substituted isoquinolines.