Spectrophotometric determination of furosemide in pharmaceuticals using permanganate
المؤلفون المشاركون
Vinay, Kanakapura Basavaiah
Basavaiah, Kanakapura
Tharpa, Kalsang
المصدر
العدد
المجلد 4، العدد 4 (31 ديسمبر/كانون الأول 2009)، ص ص. 387-397، 11ص.
الناشر
جامعة اليرموك عمادة البحث العلمي و الدراسات العليا
تاريخ النشر
2009-12-31
دولة النشر
الأردن
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Based on the reduction of permanganate by furosemide (FUR) in either acidic or basic medium, two simple, sensitive and cost-effective methods were proposed for the determination of FUR in bulk drug and in formulations.
In method A, FUR was treated with a measured excess of permanganate in acid medium and the unreacted oxidant was measured at 550 nm, whereas in method B the reaction was carried out in alkaline medium and the resulting manganite was measured at 610 nm.
In method A, the amount of permanganate reacted corresponds to the FUR content and the absorbance was found to decrease linearly with the concentration; while in method B, the absorbance increases with concentration.
Under optimum conditions, working ranges was 3.0-24.0 μ g ml-1 and 1.25-20.0 μ g ml-1 by method A and method B, respectively.
The calculated molar absorptivity's are 9.06 × 103 and 1.36 × 104 L mol-1 cm-1 for method A and method B, respectively, with corresponding Sand ell sensitivity values of 0.0365 and 0.0243 μ g cm-2.
The limits of detection (LOD) and quantification (LOQ) have also been reported.
Accuracy and precision for the assay were determined by calculating the intra-day and inter-day at three concentration levels; the intra-day RSD was < 2.7% and the accuracy was better than 2.8% (RE).
The methods were successfully applied to the determination of FUR in tablets and injections dosage forms; either in monopreparations of FUR or in combination with amyloid HCl.
The results tallied well with the label claim and were statistically compared with those of aM reference method by applying the Student’s t-test and F-test.
The accuracy was further ascertained from placebo and synthetic mixture analysis and also from spike-recovery method.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Tharpa, Kalsang& Basavaiah, Kanakapura& Vinay, Kanakapura Basavaiah. 2009. Spectrophotometric determination of furosemide in pharmaceuticals using permanganate. Jordan Journal of Chemistry،Vol. 4, no. 4, pp.387-397.
https://search.emarefa.net/detail/BIM-266497
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Tharpa, Kalsang…[et al.]. Spectrophotometric determination of furosemide in pharmaceuticals using permanganate. Jordan Journal of Chemistry Vol. 4, no. 4 (Dec. 2009), pp.387-397.
https://search.emarefa.net/detail/BIM-266497
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Tharpa, Kalsang& Basavaiah, Kanakapura& Vinay, Kanakapura Basavaiah. Spectrophotometric determination of furosemide in pharmaceuticals using permanganate. Jordan Journal of Chemistry. 2009. Vol. 4, no. 4, pp.387-397.
https://search.emarefa.net/detail/BIM-266497
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 396-397
رقم السجل
BIM-266497
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر