Perinatal outcomes after ICSI vs. spontaneously conceived pregnancies

الملخص EN

Background : the assisted reproduction techniques are more commonly used with increasing number of couple infertility and advanced technology.

The health of children born after ART has always been of concern, this study evaluate and describe perinatal outcome for births following intracytoplasmic sperm injection (ICSI) and spontaneous conception outcome.

Method : this is a retrospective, observational study according to the medical records a group of 78 newborn after intracytoplasmic sperm injection and a group of 194 newborn for spontaneous pregnant women in C-PLAS Hospital Sana'a, Yemen, who were enrolled from October 2007 to October 2009 Result : this study included (78) newborn infants for mothers where pregnancy occurred after ICSI procedure compared with 194 newborn infant born for mothers whose pregnancy occurred spontaneously.

There were a significant statistical difference in singleton in ICSI group 53 (67.9 %) versus 190 (97.9 %) in spontaneous pregnancy group.

The multifocal were 25 (32.04 %) in ICSI group versus 4 (2.0%) in spontaneous pregnancy outcomes and there was a significant statistical difference between both groups.

The number of prematurity in ICSI group was 23 with a percentage 29.48 % versus 14 (7.21 %) in spontaneous outcome and there was a statistical significant difference (34-37 weeks), while no significant difference was found (24-34 weeks of gestation).

There was a significant difference in congenital anomalies.

There was no significant difference in birth weight and prenatal death in both groups.

Conclusion : ART multiple pregnancy have a higher rate of complications such as preterm birth and LBW.

So the single embryo transfer into uterus is recommended to decrease perinatal complications.

The number of major congenital malformations is not increased compared to the general population.