Effect on hemo-dialysis on concentration of lactate dehyrogenase, creatine kinas and a-amylase in renal failure

الملخص EN

This study was conducted to compare the concentration of plasma enzymes in chronic renal failure pre dialysis (group A) and post dialysis (group B), and evaluate the concentration of these enzymes between pre and post dialysis.

The study was performed in 25 samples of Sudanese patients (chronic renal failure) and compared with 15 samples as the control groups.

Plasma samples were analyzed using spectrophotometric methods, plasma concentration of these enzymes showed increase in chronic renal failure pre and post dialysis.

The mean values of lactate dehydrogenase pre dialysis was 259IU / L, post dialysis was 276IU / L, the mean of creatine kinase pre dialysis was 252IU / L, and post dialysis was 241 IU/L but the mean of amylase pre and post dialysis was the same 144 IU / L.

This study showed that there was no difference of concentration of amylase enzyme, but the different in concentration of CK and LDH between pre and post dialysis during chronic renal failure depend on normal range of this enzyme in control groups.