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Acute renal failure following allogeneic hematopoietic cell transplantation : incidence, outcome and risk factors
المؤلفون المشاركون
Byzun, Anies
Rerolle, Jean Philipe
Morelon, Emanuel
Kreis, Henri
Bruneel-Mamzer, Marie France
Hilal, Imad
المصدر
Saudi Journal of Kidney Diseases and Transplantation
العدد
المجلد 22، العدد 3 (30 يونيو/حزيران 2011)، ص ص. 437-443، 7ص.
الناشر
تاريخ النشر
2011-06-30
دولة النشر
السعودية
عدد الصفحات
7
التخصصات الرئيسية
الموضوعات
الملخص EN
Renal insufficiency is a common complication early after hematopoietic cell transplantation (HCT).
We retrospectively examined the incidence, risk factors and associated mortality of acute renal failure (ARF) in a cohort of 101 consecutive allogeneic HCT patients.
These patients were reviewed to determine their baseline characteristics, the presence of co-morbid conditions and mortality rates at one year.
ARF was defined by the doubling of the baseline serum cretonne (Scr) levels.
The mean age of the 101 study patients was 34 ± 11.8 years.
Of them, 58 (57.4%) had ARF, yielding an incidence of 2.6% per week during the first year following HCT.
The peak frequency of ARF occurred during the second week (29.3%).
The need for hemodialysis, a proof of the severity of ARF, was seen in 12 cases (20.7%).
On univariate analysis, the Scr at one month greater than 90 μmol / L (P = 0.008), use of aminoglycosides (P < 10 -3 ), the presence of vino-occlusive disease (VOD) (P < 10 -3 ) and the need for admission to the intensive care unit (ICU) (P = 0.003) were associated with a significantly increased risk of ARF.
On multivariate analysis, the independent variables associated with an increased risk for ARF were the presence of VOD [P = 0.07, relative risk (RR) = 2.06] and use of aminoglycosides (P < 10 -3, RR = 11.2).
The overall mortality rate among the study patients was 35.6% at the end of the first year.
On multivariate analysis, only the use of aminoglycosides (P = 0.02, RR = 0.31), admission to the ICU (P < 10 -3, RR = 7.29) and the development of ARF (P = 0.001, RR = 8.97) were independent predictors of mortality.
Our study shows that ARF is highly prevalent during the early period following HCT and increases mortality, particularly if dialysis dependent.
It frequently occurs following VOD and aminoglycoside use.
As the prognosis is rather grim, it is very important that the associated factors be identified early, for an effective prevention of this disease.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Hilal, Imad& Byzun, Anies& Rerolle, Jean Philipe& Morelon, Emanuel& Kreis, Henri& Bruneel-Mamzer, Marie France. 2011. Acute renal failure following allogeneic hematopoietic cell transplantation : incidence, outcome and risk factors. Saudi Journal of Kidney Diseases and Transplantation،Vol. 22, no. 3, pp.437-443.
https://search.emarefa.net/detail/BIM-268296
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Hilal, Imad…[et al.]. Acute renal failure following allogeneic hematopoietic cell transplantation : incidence, outcome and risk factors. Saudi Journal of Kidney Diseases and Transplantation Vol. 22, no. 3 (Jun. 2011), pp.437-443.
https://search.emarefa.net/detail/BIM-268296
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Hilal, Imad& Byzun, Anies& Rerolle, Jean Philipe& Morelon, Emanuel& Kreis, Henri& Bruneel-Mamzer, Marie France. Acute renal failure following allogeneic hematopoietic cell transplantation : incidence, outcome and risk factors. Saudi Journal of Kidney Diseases and Transplantation. 2011. Vol. 22, no. 3, pp.437-443.
https://search.emarefa.net/detail/BIM-268296
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 442-443
رقم السجل
BIM-268296
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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