![](/images/graphics-bg.png)
A novel dose regimen of cinacalcet in the treatment of severe hyperparathyroidism in hemodialysis patients
المؤلفون المشاركون
al-Hilali, Nabih
Husayn, Nasir
Kawy, Yasir A.
al-Azmi, Muhammad
المصدر
Saudi Journal of Kidney Diseases and Transplantation
العدد
المجلد 22، العدد 3 (30 يونيو/حزيران 2011)، ص ص. 448-455، 8ص.
الناشر
تاريخ النشر
2011-06-30
دولة النشر
السعودية
عدد الصفحات
8
التخصصات الرئيسية
الموضوعات
الملخص EN
During the recent years, cinacalcet has markedly improved the management of hyperparathyroidism in patients on hemodialysis.
However, to the best of our knowledge, there are no specific studies addressing the dose regimen of cinacalcet.
The aim of the study was to evaluate the efficacy of cinacalcet on the achievement of targets in the treatment of hyperparathyroidism in two different dosage schedules.
Twenty-seven adult patients who were on hemodialysis for more than four months and with severe secondary hyperparathyroidism (intact parathyroid hormone (iPTH) >88 pmol / L) resistant to conventional treatment were included in this prospective study.
We used the targets of K / DOQI-clinical guidelines as optimal target of iPTH, calcium and phosphate.
Group 1 received a single daily administration of 30 mg of cinacalcet along with the main meal as the starting dose, and the dose was titrated thereafter monthly.
Group 2 received cinacalcet with the main meal twice weekly starting with a dose of 90 mg on the first day of the week and 120 mg at midweek and titrated thereafter monthly.
The levels of iPTH decreased significantly (P = 0.0001) from 124.00 ± 44.77 pmol / L to 37.78 ± 12.49 pmol / L and from 109.61 ± 53.13 pmol / L to 33.93 ± 12.03 pmol / L after 12 weeks in groups 1 and 2, respectively.
After 12 weeks, alkaline phosphatase declined significantly (P = 0.0001) from 143.42 ± 75.20 IU/L to 87.42 ± 14.46 IU/L in group 1 (P = 0.013), and from 148.00 ± 108.49 IU / L to 101.61 ± 46.62 IU/L in group 2 (P = 0.05).
There were no significant differences between the reductions of iPTH, calcium phosphate product and alkaline phosphatase levels in both the groups in the vertical comparison at the end of the study.
There was no noteworthy difference in side effects between both the groups.
Our results indicate that cinacalcet twice weekly is reasonably safe and effective in suppressing high PTH levels in hemodialysis patients, with fewer side effects.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
al-Hilali, Nabih& Husayn, Nasir& Kawy, Yasir A.& al-Azmi, Muhammad. 2011. A novel dose regimen of cinacalcet in the treatment of severe hyperparathyroidism in hemodialysis patients. Saudi Journal of Kidney Diseases and Transplantation،Vol. 22, no. 3, pp.448-455.
https://search.emarefa.net/detail/BIM-268303
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Kawy, Yasir A.…[et al.]. A novel dose regimen of cinacalcet in the treatment of severe hyperparathyroidism in hemodialysis patients. Saudi Journal of Kidney Diseases and Transplantation Vol. 22, no. 3 (Jun. 2011), pp.448-455.
https://search.emarefa.net/detail/BIM-268303
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
al-Hilali, Nabih& Husayn, Nasir& Kawy, Yasir A.& al-Azmi, Muhammad. A novel dose regimen of cinacalcet in the treatment of severe hyperparathyroidism in hemodialysis patients. Saudi Journal of Kidney Diseases and Transplantation. 2011. Vol. 22, no. 3, pp.448-455.
https://search.emarefa.net/detail/BIM-268303
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 454-455
رقم السجل
BIM-268303
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
![](/images/ebook-kashef.png)
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
![](/images/kashef-image.png)