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A phase ii study of docetaxel, cisplatin and 5- fluorouracil (TPF) in patients with locally advanced head and neck carcinomas
المؤلفون المشاركون
Ansari, M.
Mosalaei, A.
Muslih-Shirazi, M. A.
Ahmadloo, N.
Muhammadianpanah, M.
Omidvari, Shapour
المصدر
Iranian Red Crescent Medical Journal
العدد
المجلد 13، العدد 3 (31 مارس/آذار 2011)، ص ص. 187-191، 5ص.
الناشر
تاريخ النشر
2011-03-31
دولة النشر
الإمارات العربية المتحدة
عدد الصفحات
5
التخصصات الرئيسية
الموضوعات
الملخص EN
Background: The combination of cisplatin and 5-fluorouracil (PF) is currently considered a standard and effective regimen for the treatment of advanced head and neck carcinomas.
The aim of this study was to evaluate the efficacy and safety of docetaxel, cisplatin and 5-fluorouracil (TPF) in patients with unresectable head and neck carcinomas.
Methods: Forty-six patients with previously untreated non-metastatic stage IV head and neck carcinomas were enrolled.
All patients received three cycles of induction chemotherapy with docetaxel (75 mg/m2), cisplatin (40 mg/m2) (days 1-2), and 5-FU (500 mg/m2, days 1-3), repeated every 21 days.
Following induction chemotherapy, all patients underwent concurrent chemoradiotherapy using weekly cisplatin (30 mg/m2) and a median total dose of 70 Gy was delivered.
Clinical response rate and toxicity were the primary and secondary end-points of the study.
Results: There were 31 men and 15 women.
All patients had non-metastatic stage IV (T2-3N2-3 or T4N0-3) of disease.
Overall and complete response rates were 74% and 24% respectively.
Advanced T4 classification was associated with poorer response rate (p value=0.042).
The major (grade 3-4) treatment-related toxicities were myelosuppression (78%), anorexia (13%), diarrhea (7%), emesis (11%) and stomatitis/pharyngitis (24%).
Conclusion: In comparison with the data of historical published trials of the PF regimen, the TPF regimen was more effective.
However, the TPF regimen appears to be associated with a higher incidence of major toxicities.
Therefore, our limited findings support the TPF regimen as an alternative chemotherapeutic regimen for advanced head and neck carcinomas.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Ansari, M.& Omidvari, Shapour& Mosalaei, A.& Ahmadloo, N.& Muslih-Shirazi, M. A.& Muhammadianpanah, M.. 2011. A phase ii study of docetaxel, cisplatin and 5- fluorouracil (TPF) in patients with locally advanced head and neck carcinomas. Iranian Red Crescent Medical Journal،Vol. 13, no. 3, pp.187-191.
https://search.emarefa.net/detail/BIM-268332
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Ansari, M.…[et al.]. A phase ii study of docetaxel, cisplatin and 5- fluorouracil (TPF) in patients with locally advanced head and neck carcinomas. Iranian Red Crescent Medical Journal Vol. 13, no. 3 (Mar. 2011), pp.187-191.
https://search.emarefa.net/detail/BIM-268332
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Ansari, M.& Omidvari, Shapour& Mosalaei, A.& Ahmadloo, N.& Muslih-Shirazi, M. A.& Muhammadianpanah, M.. A phase ii study of docetaxel, cisplatin and 5- fluorouracil (TPF) in patients with locally advanced head and neck carcinomas. Iranian Red Crescent Medical Journal. 2011. Vol. 13, no. 3, pp.187-191.
https://search.emarefa.net/detail/BIM-268332
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 190-191
رقم السجل
BIM-268332
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
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