Renal tubular dysfunction in pediatric patients with beta-thalassemia major
المؤلفون المشاركون
Ahmadzadeh, Ali
Jalali, Umayr
Khalilian, Hamid
Pedram, Muhammad
Zandian, Khamorad
المصدر
Saudi Journal of Kidney Diseases and Transplantation
العدد
المجلد 22، العدد 3 (30 يونيو/حزيران 2011)، ص ص. 497-500، 4ص.
الناشر
تاريخ النشر
2011-06-30
دولة النشر
السعودية
عدد الصفحات
4
التخصصات الرئيسية
الموضوعات
الملخص EN
To evaluate the prevalence of renal tubular dysfunction in children with β-thalassemia (β-T) major, we studied the glomerular and tubular function in 140 children with β-T major and compared them to a healthy control group at our center from May 2007 to April 2008.
Fresh first morning samples were collected from each patient and analyzed for sodium, potassium, calcium (Ca), protein, uric acid (UA), cretonne (Cr), urine osmolality and urinary N-acetyl-β-D-glucosaminidase (UNAG) activity.
Blood samples were also collected for complete blood count, blood urea nitrogen (BUN), fasting blood sugar, serum cretonne (SCr), electrolytes, and ferritin before transfusion.
Among the study patients, 72 were males, and the mean age was 11.5 (ranging 7-16) years.
SCr levels were all within normal limits and all of them had normal glomerular filtration rate (GFR).
The mean UNAG was 17.8 IU / L in the study patients (normal 0.15-11.5 IU / L) and 3.2 IU / L in the control group (P < 0.001).
Of the 82 study patients who had elevated level of UNAG, 58 (62.4%) had high blood levels of ferritin also (r = 0.2, P < 0.001) and 13 (15.9%) patients had hypercalciuria also (UCa / UCr > 0.21) (P = 0.006).
Nine (6.4%) thalassemia patients with a mean age of 12 years had proteinuria (Upr / UCr > 0.2).
Sixty-nine (49.3%) out of the 140 patients and 45 (65.2%) of the patients having UNAG had uricosuria also (UUA / UCr > 0.26).
Ten (7%) patients had microscopic hematuria and 10 (7%) patients with a mean age of 13.5 years had glycosuria or diabetes mellitus.
We conclude that tubular dysfunction is a relative common complication of the β-T major; UNAG and its index are the best to detect renal tubular dysfunction in these patients.
Currently, periodic measurement of UCa / UCr and UUA / UCr ratios as well as urinalysis is recommended.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Ahmadzadeh, Ali& Jalali, Umayr& Khalilian, Hamid& Zandian, Khamorad& Pedram, Muhammad. 2011. Renal tubular dysfunction in pediatric patients with beta-thalassemia major. Saudi Journal of Kidney Diseases and Transplantation،Vol. 22, no. 3, pp.497-500.
https://search.emarefa.net/detail/BIM-268341
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Ahmadzadeh, Ali…[et al.]. Renal tubular dysfunction in pediatric patients with beta-thalassemia major. Saudi Journal of Kidney Diseases and Transplantation Vol. 22, no. 3 (Jun. 2011), pp.497-500.
https://search.emarefa.net/detail/BIM-268341
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Ahmadzadeh, Ali& Jalali, Umayr& Khalilian, Hamid& Zandian, Khamorad& Pedram, Muhammad. Renal tubular dysfunction in pediatric patients with beta-thalassemia major. Saudi Journal of Kidney Diseases and Transplantation. 2011. Vol. 22, no. 3, pp.497-500.
https://search.emarefa.net/detail/BIM-268341
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 500
رقم السجل
BIM-268341
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر