Effects of fasciliasis and schistosomiasis mansoni on the anti-oxidant defense mechanisms

الملخص EN

Background / Aim : medical and surgical problems especially in tropical and subtropical areas arise frequently from helminthic invasion affecting the liver and/or biliary tract Tate antioxidant enzymes have a potential role evasion of the oxidative burst killing mechanisms by the immune cells.

The aim of this study was to evaluate the influence on hepato-Miary system posed by Fascia species with or without Schist soma mansion co-infection respective to tie antioxidant status, total bile acids and liter function tests.

Subjects & Methods : Thirty subjects infected with Fascia hepatica were categorized into those with S.

mansion infection (GI) and without S.

mansion infection (GI) compared to thirty age matched subjects free of Fascicle hepatica but with S.

mansion infection (Gil) and a fourth group including frailty subjects as controls (QV).

Ultrasonography computed tomography (CI).

Arid endoscopic retrograde choline pancreatography (EKCP) as well as antifasciola antibody titer were used for diagnosis of early and late stages of fascioliasis.

Diagnosis of schistosomiasis mansion was done by stool examination for eggs, sigmoidoscopy and rectal snips for negative stool.

In addition, abdominal ultrasonography was done for diagnosis of per portal fibrosis.

Biochemical assessments of the antioxidant defense status by measuring serum lewd of enzymatic activity of superoxide dismutase, catalase, and total jiutathiore peroxidase, and vitamins AC and E were doer as well as total serum bile acids and liver function tests.

Results : significant reduced levels of superoxide dismutase, catalase and glutathione peroxidase as well as the antioxidant vitamins AC E in groups Llano as compared to GIV and the decrease was highly significant with mixed parasitic infection (GI) (P < 0.01).

The serum total bile acids were significantly increased in GI and Gil as compared to Gil and GIV (p < 0.05) ; meanwhile the liver function tests were significantly higher in patients with Fascia (GI, Gil) than those with S.mansoni alone or in healthy control (GEIGIV).

Conclusion : Tie serum antioxidant enzymes superoxide dismutase, catalase, and glutathione peroxidase as well as the antioxidant vitamins A,C and E were statistically significantly decreased in patients with fascioliasis, schistosomiasis mansion and with co-infection than in healthy control versus increased levels of total bile adds.

These findings potentiate the fibro genic mechanisms and necessitate the supplementation of antioxidants in combination with traditional therapy.