Serum lipid, steatosis and fibrosis in patients with chronic hepatitis C genotype 4

الملخص EN

Background / Aim : Alterations of lipid metabolism are commonly observed in chronic Hepatitis.

Statuses are present on liver biopsy in approximately 50 % of patients with hepatitis C and its association with stage of fibrosis has been report ted.

Relations of serum lipid, statuses and fibrosis to HCV genotype 4 are unknown.

The aim of this work is to study the relation between serum lipids, statuses art! Fibrosis and hepatitis C genotype4.

Patients & Methods : we studied 47 patients (31 males, 16 females, mean age 41.8 + 17.58 years) with chronic HCV infection.

Serum lipid profile was determined in all participants after an overnight fast of 12 h Hepatitis C virus RNA was detected in patients' sera by reverse transcriptase-polymerase chain reaction (RT-PR).

Liver biopsies were taken to evaluate steaosisand fibrosis Results : serum Total cholesterol (p < 0.001) and Low-density lipoprotein-cholesterol (p < 0.001), were significantly lower in chronic hepatitis C patients with genotype 4.

Aspartate aminotransferases (AST), alanine aminotransferase (ALT) (p < 0.001), were significantly higher in chronic hepatitis pains compared with control's.

There was a significant difference between chronic hepatitis subgroups (as regard degree of statuses) grading and staging (p < 0.001).

Conclusions : HCV-genotype 4 infection is associated with clinically significant lower cholesterol levels (TC, and LDL) than those of normal subjects.

We have confirmed that statuses are associated with increased fibrosis & necroinflammation in chronic HV biopsies.