Effect of dermal exposure of diethanolamine on the testes and sperms of adult albino rats

الملخص EN

Background / Aim : occupational exposure to ethanolamine may occur by skin contact during the use of DEA in various processes in machine building, metallurgy and other industries.

DEA is released to the environment in emissions from sites of its manufacture or industrial use.

As it is readily absorbed through the skin, the aim of the present study was to assess the potential toxic effects of dietharolamineonthetestis and sperms after its dermal application.

Arterials & etudes : 36 adult male abler.

Rats were used in this study.

They were divided into2 groups according to duration of dermal exposure (2 weeks and 13 weeks).

Eachwasdividedintointo4 groups (one control group and other 3 treated groups according to the dose of DEA applied to the skin).The right testes and epididymis were extracted, the testes were processed for histological exams nation while the elided yams was used for emenexa minutia n Results : considering the testes, The 2 weeks exposed rat testes showed degeneration of the somniferous tubules with narrowing of tie interstitial spices there were spermatogenic cdl loss, interstitial hemorrhage art! Degenerated Leyden cells.

With increasing the dose and duration of exposure (13 weeks), cellular infiltration in the interstitial spaces and degeneration of the Leyden cells were manifest.

Widespread atrophy of the testicular tissues and reduction in sizes of the semirefrous tubules were obvious with very little number of sperms in the Lumina of the tubules and wide interstitial spaces.

Considering tie sperms, the results showed significant decrease in sperm cell counts in all DEA treated groups and decreased sperm motility for all DEA treated groups except those exposed to 500 mg / kg for 2 weeks.

There was also significant increase in the frequency of epididymis spermabnormalitiesinall DEA treated groups.

Conclusion: der mal an application of di ethanol mine is toxic to the testes and has adverb se effects on sperms.

If expos urea to DEA is inevitable as in occupational exposure, it is recommended to rinse off the product thoroughly after use and to use protective dotesarri gloves tall workers to decrease the risk of cutaneous absorption of DEA.