indium-mediated allylation of a-tert-butylsulfinylaldimines with dimethyl 2-[2-(chloromethyl)‎allyl]malonate

الملخص EN

The reaction of N-fert-butylsulfinylaldimines 5 with dimethyl 2-[2-(chloromethyl) allyl]-malonate (10), in the presence of indium metal and sodium iodide, at room temperature for 72 hours, led to the corresponding amino ester derivative 11.

The reaction proceeded in high yields and in a total stereoselective fashion, a single diastereoisomer being always isolated.