Toxicological studies of hexachloroethane and rafoxanide on goat

الملخص EN

The toxic effects of different levels of fasciolicidal drugs, namely hexachloroethane and rafaxonide on crossbreed Nubian goat were investigated.

The main clinical signs in goats that received hexachloroethane were tympany, salivation, diarrhea and nervous signs accompanied by incoordination, staggering, twitching in neck, paddling, paralysis and recumbency.

These signs were transient in goats given recommended dose (29.5 g / goat) but more severe in those that received one and half the recommended dose (44.25 g / goat).

The goats drenched with 44.25 g / animal, and died within 10 hours to 6 days.

The goats that received 29.5 g / animal showed no gain in body weights.

In both groups, lesions included liver fatty changes, proliferation of bile ducts, congestion, haemosiderosis and haemorrhages.

Mononuclear cellular infiltration was evident in the kidney and intestine.

Goats that received rafoxanide at the therapeutic dose (3 ml / 10 kg animal weight) and triple the recommended dose (9 ml / 10 kg animal weight) showed an increase in body weights gain.

There were no clinical signs or histopathological changes observed.