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Clinical significance of p-glycoprotein immunohistochemistry and histomorphologic factors in patients with osteosarcoma
المؤلفون المشاركون
Rezazadeh, S.
Pakbaz, Sarah
Torabi Nezhad, S.
Jaberi, F. Mojtahed
Saalabian, M. J.
المصدر
Iranian Red Crescent Medical Journal
العدد
المجلد 11، العدد 3 (31 يوليو/تموز 2009)، ص ص. 277-285، 9ص.
الناشر
تاريخ النشر
2009-07-31
دولة النشر
الإمارات العربية المتحدة
عدد الصفحات
9
التخصصات الرئيسية
الموضوعات
الملخص EN
Background : osteosarcoma is the most frequent highly malignant bone tumor with a peak incidence in the second decade of life.
Although survival rate increased up to 60-70 % within the last 10 years, the problem of unresponsiveness to chemotherapy remains.
In this study, we sought to determine the prognostic significance of P-glycoprotein as a tumor marker for osteosarcoma.
Methods : in a retrospective study, we correlated P-glycoprotein immunostaining with clinic pathologic and histomorphologic features of the tumor and the patient outcome in 30 cases with primary, non-metastatic, high-grade osteosarcoma who were homogeneously treated.
Results : P-glycoprotein positivity was found in 14 of 30 cases and was significantly associated with a higher incidence of adverse events and relapse rate.
No relationship was found between p-glycoprotein immunostaining and clinic pathologic features such as age, sex, tumor site, histologic subtype, osteoid content, osteoid pattern, pretreatment necrosis, pleomorphism of the cells, and presence of prominent nucleoli, except for mitotic activity per 10 HPF.
Conclusions : P-glycoprotein positivity in immunohistochemistry should be taken into consideration to identify a subgroup of osteosarcoma patients with poor outcome at the time of diagnosis.
So it might be an important marker in planning innovative chemotherapeutic regimens.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Pakbaz, Sarah& Torabi Nezhad, S.& Jaberi, F. Mojtahed& Saalabian, M. J.& Rezazadeh, S.. 2009. Clinical significance of p-glycoprotein immunohistochemistry and histomorphologic factors in patients with osteosarcoma. Iranian Red Crescent Medical Journal،Vol. 11, no. 3, pp.277-285.
https://search.emarefa.net/detail/BIM-27344
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Pakbaz, Sarah…[et al.]. Clinical significance of p-glycoprotein immunohistochemistry and histomorphologic factors in patients with osteosarcoma. Iranian Red Crescent Medical Journal Vol. 11, no. 3 (Jul. 2009), pp.277-285.
https://search.emarefa.net/detail/BIM-27344
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Pakbaz, Sarah& Torabi Nezhad, S.& Jaberi, F. Mojtahed& Saalabian, M. J.& Rezazadeh, S.. Clinical significance of p-glycoprotein immunohistochemistry and histomorphologic factors in patients with osteosarcoma. Iranian Red Crescent Medical Journal. 2009. Vol. 11, no. 3, pp.277-285.
https://search.emarefa.net/detail/BIM-27344
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 285
رقم السجل
BIM-27344
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
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