Assessment of the reliability of immunocytochemical detection of estrogen and progesterone receptors status on the cytological aspirates of breast carcinoma
المؤلفون المشاركون
Hafiz, Nisrin H.
Tahun, Nifin S.
المصدر
Journal of the Egyptian National Cancer Institute
العدد
المجلد 22، العدد 4 (31 ديسمبر/كانون الأول 2010)، ص ص. 217-225، 9ص.
الناشر
جامعة القاهرة المعهد القومي للأورام
تاريخ النشر
2010-12-31
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الموضوعات
الملخص EN
Purpose : evaluation of the reliability of immunocytochemical staining for estrogen and progesterone receptor status on previously papanicolaou-stained fine needle aspiration smears of breast carcinoma cases.
Patients and Methods : this is a retrospective study conducted on detained smears of fine needle aspirates (FNA) obtained from 90 breast carcinoma cases.
These cases underwent subsequent tumor resection and immunohistochemical detection of estrogen and progesterone receptors allowing a comparison between the immunocytochemical and immunohistochemical results (Gold Standard).
Hypocelluar slides were excluded from the current study.
Only the nuclear staining was considered specific.
The results were scored on the basis of the percentage of the positive nuclei among the total epithelial malignant cells after examination of the entire slide.
Smears were interpreted as positive if ³10 % of the examined cells demonstrated nuclear staining.
These results were then compared with the immunohistochemical results.
Results : for estrogen receptor immunocytochemistry, the overall cyto-histologic accuracy was 91.1 % (82 / 90).
while the discordance rate was 8.9 % (8 / 90).
The diagnostic sensitivity, specificity, positive predictive value, and negative predictive value were 93 %, 84.2 %, 95.7 %, and 76.2 % respectively.
For progesterone receptor immunocytochemistry, the overall cyto-histologic accuracy was 88.9 % (80 / 90) while the discordance rate was 11.1 % (10 / 90).
The diagnostic sensitivity, specificity, positive predictive value, and negative predictive value were 87.1%, 95 %, 98.4 %, and 67.9% respectively.
Conclusion : immunocytochemistry is considered as an efficient tool in evaluating estrogen and progesterone receptor status in breast carcinoma.
The application of estrogen and progesterone receptor immunocytochemistry on previously Papanicolaou-stained slides provides an overall accuracy of 91.1 % for estrogen receptor and 88.9 % for progesterone receptor when compared with the immunohistochemical results.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Hafiz, Nisrin H.& Tahun, Nifin S.. 2010. Assessment of the reliability of immunocytochemical detection of estrogen and progesterone receptors status on the cytological aspirates of breast carcinoma. Journal of the Egyptian National Cancer Institute،Vol. 22, no. 4, pp.217-225.
https://search.emarefa.net/detail/BIM-273739
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Hafiz, Nisrin H.& Tahun, Nifin S.. Assessment of the reliability of immunocytochemical detection of estrogen and progesterone receptors status on the cytological aspirates of breast carcinoma. Journal of the Egyptian National Cancer Institute Vol. 22, no. 4 (Dec. 2010), pp.217-225.
https://search.emarefa.net/detail/BIM-273739
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Hafiz, Nisrin H.& Tahun, Nifin S.. Assessment of the reliability of immunocytochemical detection of estrogen and progesterone receptors status on the cytological aspirates of breast carcinoma. Journal of the Egyptian National Cancer Institute. 2010. Vol. 22, no. 4, pp.217-225.
https://search.emarefa.net/detail/BIM-273739
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 224-225
رقم السجل
BIM-273739
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر