Evaluation of neoplastic nature of keratocystic odontogenic tumor versus ameloblastoma
المؤلفون المشاركون
Khalifah, Ghadah A.
Shuqayr, Hanan M.
Abu Hajar, Iman A.
المصدر
Journal of the Egyptian National Cancer Institute
العدد
المجلد 22، العدد 1 (31 مارس/آذار 2010)، ص ص. 61-72، 12ص.
الناشر
جامعة القاهرة المعهد القومي للأورام
تاريخ النشر
2010-03-31
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الموضوعات
الملخص EN
Objective : Although most of odontogenic tumors are benign, some of them will show locally destructive behavior, as keratocystic odontogenic tumor (KCOT) is now known as a benign but aggressive odontogenic neoplasm.
The neoplastic characteristics in KCOT have been suggested from clinical as well as pathologic aspects.
Matrix metalloproteinase-2 (MMP-2) is a gelatinize form of the MMPs family, which is a group of proteolysis enzymes that degrade many types of collagen.
Cysteine aspartic acid-specific protease-3 (caspase-3) is the most downstream enzyme in the apoptosis-inducing protease pathway and is probably the most clearly associated with cell death.
The aim of this study is to evaluate and compare the extracellular degradation potentiality (MMP-2) and apoptosis (caspase-3) of the epithelial lining in KCOT versus radicular cysts and ameloblastoma, in order to reinforce its classification as an odontogenic tumor.
Material and Methods : Twenty-six surgical specimens including keratocyst odontogenic tumor (KCOT ; n = 11).
ameloblastoma (AB; n=8) and radicular cysts (RC ; n = 7) were examined for expression of MMP-2 and caspase-3 using the immunohistochemical method.
Results : For MMP-2 immunoexpression, AB showed the statistically significant highest mean area percentage, followed by KCOT, while RC showed the statistically significant lowest mean area percentage.
As for capsize 3, there was no statistically significant difference between KCOT and AB, while RC showed the statistically significantly lowest mean area percentage.
Conclusion : overexpression of MMP-2 protein related to growth and progression of lesions analyzed and may be one of the factors enhancing the recurrence of KCOT and invasion of AB.
In addition, the epithelial lining of KCOT showed a high cell turnover reinforcing its classification as an odontogenic tumor.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Khalifah, Ghadah A.& Shuqayr, Hanan M.& Abu Hajar, Iman A.. 2010. Evaluation of neoplastic nature of keratocystic odontogenic tumor versus ameloblastoma. Journal of the Egyptian National Cancer Institute،Vol. 22, no. 1, pp.61-72.
https://search.emarefa.net/detail/BIM-273868
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Khalifah, Ghadah A.…[et al.]. Evaluation of neoplastic nature of keratocystic odontogenic tumor versus ameloblastoma. Journal of the Egyptian National Cancer Institute Vol. 22, no. 1 (Mar. 2010), pp.61-72.
https://search.emarefa.net/detail/BIM-273868
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Khalifah, Ghadah A.& Shuqayr, Hanan M.& Abu Hajar, Iman A.. Evaluation of neoplastic nature of keratocystic odontogenic tumor versus ameloblastoma. Journal of the Egyptian National Cancer Institute. 2010. Vol. 22, no. 1, pp.61-72.
https://search.emarefa.net/detail/BIM-273868
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 70-72
رقم السجل
BIM-273868
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر