Sequence of radiation therapy and chemotherapy as adjuvant treatment in breast cancer
المؤلفون المشاركون
Abu al-Humr, Abd al-Halim M.
Barakat, Ashraf F.
al-Gantiry, Mahmud M.
Nasif, Hibah H.
المصدر
Journal of the Egyptian National Cancer Institute
العدد
المجلد 22، العدد 1 (31 مارس/آذار 2010)، ص ص. 95-104، 10ص.
الناشر
جامعة القاهرة المعهد القومي للأورام
تاريخ النشر
2010-03-31
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الموضوعات
الملخص EN
Purpose : the aim of the work was to evaluate the prognostic importance of the sequence of radiotherapy (RT) and chemotherapy (CT) as adjuvant treatment in women with breast cancer who were treated with modified radical mastectomy or total mastectomy and their correlation also with other known prognostic factors.
Methods : In this retrospective study, 200 women with breast cancer were evaluated.
The age ranged from 25 to 73 years, with the mean age of 44 years; 125 patients had stage II and 75 had stage III disease.
All were subjected to mastectomy.
The influence of the following prognostic factors were evaluated : Age, histological grade, nodal status, number of positive nodes, tumor size, estrogen receptor status, menstrual status and as well as the sequence of radiotherapy and chemotherapy on 5-year loco regional disease free survival, 5-year systemic disease-free survival, and 5-year overall survival.
Results : the 5-year loco regional disease free survival was 90.9 % for the entire patient population.
Nodal status, number of positive nodes and estrogen receptor status was prognostic ally significant for loco regional recurrence.
The 5-year systemic disease-free survival was 67.6 % for the whole group.
On univariate analysis, the presence of positive axillary nodes, grade III tumor, ER-negative disease and radiotherapy first followed by chemotherapy, were independent poor risk factors for systemic recurrence.
The 5-year overall survival was 71.8%.
On univariate analysis, the presence of positive axillary nodes, grade III tumor, ER-negative disease and radiotherapy first followed by chemotherapy, were independent poor risk factors for death from breast cancer.
Conclusions : In patients with breast cancer, a treatment protocol consisting of 6 cycles of CT followed by RT resulted in a better 5-year OS and DFS, and was easier to administer when compared with other treatment protocols.
Ideal candidates are those with early-stage, age > 35 years, low tumor grade, positive ER, and absence of positive axillary lymph nodes.
Longer follow-up will be necessary to assess efficacy and a randomized clinical trial that included a group for simultaneous comparison would be required to produce definitive results.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Abu al-Humr, Abd al-Halim M.& Barakat, Ashraf F.& al-Gantiry, Mahmud M.& Nasif, Hibah H.. 2010. Sequence of radiation therapy and chemotherapy as adjuvant treatment in breast cancer. Journal of the Egyptian National Cancer Institute،Vol. 22, no. 1, pp.95-104.
https://search.emarefa.net/detail/BIM-273887
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Abu al-Humr, Abd al-Halim M.…[et al.]. Sequence of radiation therapy and chemotherapy as adjuvant treatment in breast cancer. Journal of the Egyptian National Cancer Institute Vol. 22, no. 1 (Mar. 2010), pp.95-104.
https://search.emarefa.net/detail/BIM-273887
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Abu al-Humr, Abd al-Halim M.& Barakat, Ashraf F.& al-Gantiry, Mahmud M.& Nasif, Hibah H.. Sequence of radiation therapy and chemotherapy as adjuvant treatment in breast cancer. Journal of the Egyptian National Cancer Institute. 2010. Vol. 22, no. 1, pp.95-104.
https://search.emarefa.net/detail/BIM-273887
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 103-104
رقم السجل
BIM-273887
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر