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Immunohistochemical study of the effect ofnigellasativalextractonchemotherapy induced oral mucositis in albino rats
المؤلفون المشاركون
Lutfi, Alia Umar
Zayid, Muhammad
المصدر
العدد
المجلد 25، العدد 2 (30 مايو/أيار 2009)، ص ص. 159-166، 8ص.
الناشر
جامعة القاهرة كلية طب الفم و الأسنان
تاريخ النشر
2009-05-30
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الموضوعات
الملخص EN
Background: Mucositis is a common side-effect of high-dose chemotherapy regimens.
The black seed Nigella sativa L (NS) represents a rich source of thymoquinone (TQ) with the potential to exert anti-inflammatory and anti-neoplastic effects.
We evaluated NS for its capacity to decrease the severity of chemotherapy-induced mucositis in a rat model.
METHOD: twenty five male albino rats were randomly divided into control group, untreated group and treated group.
A model of chemotherapy induced mucositis was established by intraperitoneal injection of 5- flouro-uracil (FU) [150 mg/kg] and the right cheek pouch was scratched with a wire brush to induce mucositis.
Rats in the untreated group received physiologic saline orally.
The rats in treated group were gavaged with 1 ml NS seed extract (400 mg/kg) daily (day 5-13).
Rats were sacrificed at day 14, the cheek pouch areas were excised and prepared for histological and immunohistochemical analysis using Bcl-2 and PCNA immunolabelling.
Results : Compared with controls and 5-FU untreated rats, NS decreased the histologically observed damage of the cheek mucosa in the mucositis model, reduced Bcl-2 immunoreactivity and increased expression of PCNA.
Based on these observations NS seemed to attenuate the 5-FU-induced reduction of mucosal thickness and ameliorate oral mucosal damage induced by 5-FU in rats.
NS may represent a promising prophylactic adjunct to conventional chemotherapy for reducing the severity of oral mucositis.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Lutfi, Alia Umar& Zayid, Muhammad. 2009. Immunohistochemical study of the effect ofnigellasativalextractonchemotherapy induced oral mucositis in albino rats. Cairo Dental Journal،Vol. 25, no. 2, pp.159-166.
https://search.emarefa.net/detail/BIM-274124
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Lutfi, Alia Umar& Zayid, Muhammad. Immunohistochemical study of the effect ofnigellasativalextractonchemotherapy induced oral mucositis in albino rats. Cairo Dental Journal (May. 2009), pp.159-166.
https://search.emarefa.net/detail/BIM-274124
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Lutfi, Alia Umar& Zayid, Muhammad. Immunohistochemical study of the effect ofnigellasativalextractonchemotherapy induced oral mucositis in albino rats. Cairo Dental Journal. 2009. Vol. 25, no. 2, pp.159-166.
https://search.emarefa.net/detail/BIM-274124
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 165-166
رقم السجل
BIM-274124
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
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