Immunohistochemical study of the effect ofnigellasativalextractonchemotherapy induced oral mucositis in albino rats
المؤلفون المشاركون
Lutfi, Alia Umar
Zayid, Muhammad
المصدر
العدد
المجلد 25، العدد 2 (30 مايو/أيار 2009)، ص ص. 159-166، 8ص.
الناشر
جامعة القاهرة كلية طب الفم و الأسنان
تاريخ النشر
2009-05-30
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الموضوعات
الملخص EN
Background: Mucositis is a common side-effect of high-dose chemotherapy regimens.
The black seed Nigella sativa L (NS) represents a rich source of thymoquinone (TQ) with the potential to exert anti-inflammatory and anti-neoplastic effects.
We evaluated NS for its capacity to decrease the severity of chemotherapy-induced mucositis in a rat model.
METHOD: twenty five male albino rats were randomly divided into control group, untreated group and treated group.
A model of chemotherapy induced mucositis was established by intraperitoneal injection of 5- flouro-uracil (FU) [150 mg/kg] and the right cheek pouch was scratched with a wire brush to induce mucositis.
Rats in the untreated group received physiologic saline orally.
The rats in treated group were gavaged with 1 ml NS seed extract (400 mg/kg) daily (day 5-13).
Rats were sacrificed at day 14, the cheek pouch areas were excised and prepared for histological and immunohistochemical analysis using Bcl-2 and PCNA immunolabelling.
Results : Compared with controls and 5-FU untreated rats, NS decreased the histologically observed damage of the cheek mucosa in the mucositis model, reduced Bcl-2 immunoreactivity and increased expression of PCNA.
Based on these observations NS seemed to attenuate the 5-FU-induced reduction of mucosal thickness and ameliorate oral mucosal damage induced by 5-FU in rats.
NS may represent a promising prophylactic adjunct to conventional chemotherapy for reducing the severity of oral mucositis.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Lutfi, Alia Umar& Zayid, Muhammad. 2009. Immunohistochemical study of the effect ofnigellasativalextractonchemotherapy induced oral mucositis in albino rats. Cairo Dental Journal،Vol. 25, no. 2, pp.159-166.
https://search.emarefa.net/detail/BIM-274124
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Lutfi, Alia Umar& Zayid, Muhammad. Immunohistochemical study of the effect ofnigellasativalextractonchemotherapy induced oral mucositis in albino rats. Cairo Dental Journal (May. 2009), pp.159-166.
https://search.emarefa.net/detail/BIM-274124
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Lutfi, Alia Umar& Zayid, Muhammad. Immunohistochemical study of the effect ofnigellasativalextractonchemotherapy induced oral mucositis in albino rats. Cairo Dental Journal. 2009. Vol. 25, no. 2, pp.159-166.
https://search.emarefa.net/detail/BIM-274124
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 165-166
رقم السجل
BIM-274124
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر