A common mutation in methylene tetrahydrofolate reductase gene, inflammation and atherosclerosis in chronic renal failure.
العناوين الأخرى
الطفرة الجينية الشائعة لإنزيم التتراهيروفوليت ريداكتيزو الالتهاب وتصلب الشرايين في مرضى الفشل الكلوي المزمن
المؤلفون المشاركون
al-Baz, Muna Abd al-Hamid
Hasan, Husni Ali
Abu Zayd, Husam
Mustafa, Taha Sayyid
Subuh, Muhammad Abbas
المصدر
العدد
المجلد 35، العدد 2 (31 مايو/أيار 2011)، ص ص. 51-60، 10ص.
الناشر
تاريخ النشر
2011-05-31
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الموضوعات
الملخص EN
Background: Accelerated atherosclerosis is the major cause of mortality in patients on chronic haemodialysis (HD).
Inflammation and endothelial activation or dysfunction might be the major factors leading to high cardiovascular mortality rate in HD patients.
Also, C667T mutation of methyltetrahydrofolate reductase (MTHFR) might be associated with accelerated atherosclerosis.
Aim: The present study was designed to clarify the role of inflammation, endothelial activation or dysfunction and genotyping of MTHFR enzyme which affect the level of homocysteine and their relation to carotid artery intima-media thickness (CIMT) as an indicator of atherosclerosis.
Subjects & Methods: Forty four (44) chronic haemodialysis (HD) patients and 40 healthy subjects were included in the study.
Serum highly sensitive C reactive protein (hs-CRP) and IL-6 were measured as inflammatory markers, soluble vascular cell adhesion molecule-l (sVCAM-1) was measured as a marker of endothelial activation and dysfunction.
Common carotid intimal media thickness (CC-IMT) was assessed by carotid artery ultrasonography, genotyping of MTHFR enzyme which affect the level of homocysteine was analyzed by PCR RFLIP technique.
Results: Chronic HD patients had elevated levels of inflammatory markers (hs-CRP and IL-6), enhanced endothelial activation or dysfunction demonstrated by elevated VCAM-1 as compared by healthy controls, Haemodialysis patients had significantly higher CC-IMT levels.
There is a significant positive correlation between inflammatory cytokines (hs-CRP and IL-6), and each with VCAM-1 and CC-IMT There is no difference in the genotype of C667T MTHFR found between patients and controls, but this mutation especially the TT genotype is associated with development of atherosclerosis as indicated by the increase of CC-IMT.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Hasan, Husni Ali& Subuh, Muhammad Abbas& al-Baz, Muna Abd al-Hamid& Abu Zayd, Husam& Mustafa, Taha Sayyid. 2011. A common mutation in methylene tetrahydrofolate reductase gene, inflammation and atherosclerosis in chronic renal failure.. Assiut Medical Journal،Vol. 35, no. 2, pp.51-60.
https://search.emarefa.net/detail/BIM-274264
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Hasan, Husni Ali…[et al.]. A common mutation in methylene tetrahydrofolate reductase gene, inflammation and atherosclerosis in chronic renal failure.. Assiut Medical Journal Vol. 35, no. 2 (May. 2011), pp.51-60.
https://search.emarefa.net/detail/BIM-274264
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Hasan, Husni Ali& Subuh, Muhammad Abbas& al-Baz, Muna Abd al-Hamid& Abu Zayd, Husam& Mustafa, Taha Sayyid. A common mutation in methylene tetrahydrofolate reductase gene, inflammation and atherosclerosis in chronic renal failure.. Assiut Medical Journal. 2011. Vol. 35, no. 2, pp.51-60.
https://search.emarefa.net/detail/BIM-274264
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 58-60
رقم السجل
BIM-274264
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر