عزل أشباه القلويدات الكلية من بذور نبات Datura metel L. و اختبار فعاليتها المضادة على بعض الجراثيم و مهدبات طفيلي Fasciola gigantica وأختبار تأثيرها السام في الفئران المختبرية

الملخص EN

In this study, isolated of the total alkaloid has been done from Dauura metal, in vitro antibacterial activity was evaluated against negative and positive Gram bacteria, in addition to testing of their activity against meracidia ofFascioIa gigantica.

The toxicity test and histological study were examined and the result showed that the total alkaloid was very toxic with oral LD50 as 0.18 g/kg, the results also indicated that females were more tolerant than males.

The pathological changes were clearly evident, dose dependent and varying in severity from precipitate of alkaloid in the spleen and heart to the acute inflammation and nercosis in the liver, kidney and lung in addition to ulceration of small and large intestine.