A comparison of isosorbide mononitrate, misoprostol and combination therapy for preinduction cervical ripening at term : a randomized controlled trial
المؤلفون المشاركون
Sanad, Zakariyya
Ubayd, Usamah Muhammad
المصدر
Tanta Medical Sciences Journal
العدد
المجلد 1، العدد 4 (31 ديسمبر/كانون الأول 2006)، ص ص. 69-82، 14ص.
الناشر
تاريخ النشر
2006-12-31
دولة النشر
مصر
عدد الصفحات
14
التخصصات الرئيسية
الموضوعات
الملخص EN
Aim : the purpose of this study was to compare the efficacy, safety, and acceptability of isosorbide mononitrate (IMN), misoprostol, and the combination therapy for cervical ripening before induction of labor at term.
Patients and Methods : A prospective, double-blind, placebo-controlled, randomized clinical trial in 196 term and post-term nulliparous women with unfavorable cervices who were assigned randomly to receive either 40mg of IMN (n = 65), 50p.g of misoprostol (n = 65), or both of them (n = 66) in the posterior vaginal fornix.
Changes in Bishop score and cervical length, progress and outcomes of labor and adverse effects were assessed.
Results : the combination therapy was more effective than IMN or misoprostol.
Successful induction (vaginal delivery within 24 h of initiation of cervical ripening) was significantly higher in the misoprostol (60 %) and combination therapy (62.1 %) groups compared with the IMN (27.7 %) group (P < 0.0001).
Mean duration (h) from treatment initiation to delivery was greater for IMN (26.7 + 7.5) than misoprostol (16.5 + 6.7) and combination therapy (14.8 + 6.2) groups (P < 0.0001).
Oxytocin was needed more in the IMN group (93.8 %) than in the misoprostol (21.5 %) and combination therapy (25.8 %) groups (P < 0.0001).
IMN was safer and more acceptable than misoprostol and combination therapy.
The cesarean rate was not significantly different among groups, but the major indications were different : dystocia (54.5 %) in the IMN group versus persistent non-reassuring FHR pattern (57.9 %) in the misoprostol and (47.6 %) in the combination therapy groups (P = 0.01).
Conclusion : the combination therapy was more effective than either IMN or misoprostol alone for preinduction cervical ripening at term.
However, IMN was safer, well tolerated and more acceptable.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Sanad, Zakariyya& Ubayd, Usamah Muhammad. 2006. A comparison of isosorbide mononitrate, misoprostol and combination therapy for preinduction cervical ripening at term : a randomized controlled trial. Tanta Medical Sciences Journal،Vol. 1, no. 4, pp.69-82.
https://search.emarefa.net/detail/BIM-277583
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Sanad, Zakariyya& Ubayd, Usamah Muhammad. A comparison of isosorbide mononitrate, misoprostol and combination therapy for preinduction cervical ripening at term : a randomized controlled trial. Tanta Medical Sciences Journal Vol. 1, no. 4 (Dec. 2006), pp.69-82.
https://search.emarefa.net/detail/BIM-277583
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Sanad, Zakariyya& Ubayd, Usamah Muhammad. A comparison of isosorbide mononitrate, misoprostol and combination therapy for preinduction cervical ripening at term : a randomized controlled trial. Tanta Medical Sciences Journal. 2006. Vol. 1, no. 4, pp.69-82.
https://search.emarefa.net/detail/BIM-277583
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 81-82
رقم السجل
BIM-277583
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر