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Reduction of the severity of ischemia reperfusion-induced pancreatitis by ischemic pre-conditioning of the liver
المؤلفون المشاركون
Mansoorian, Muhsin Rida
Husayn, Sayyid Muhammad Fahd
Mardani, Parviz
Nikeghbalian, Sama
Malik Husayni, Sayyid Ali
Gerami zadah, Bita
المصدر
Saudi Journal of Kidney Diseases and Transplantation
العدد
المجلد 20، العدد 6 (31 ديسمبر/كانون الأول 2009)، ص ص. 1010-1014، 5ص.
الناشر
تاريخ النشر
2009-12-31
دولة النشر
السعودية
عدد الصفحات
5
التخصصات الرئيسية
الموضوعات
الملخص EN
Pre-conditioning by brief exposure to ischemia does not only protect the concerned organ against subsequent severe ischemic damage, but also has protective effect on other organs, which is called remote pre-conditioning.
Our aim in this study was to evaluate the protective effect of brief liver ischemia on the pancreas against severe ischemia-reperfusion-induced pancreatitis.
This study was performed on 30 male waster rats.
Ischemic pre-conditioning of liver was performed by first clamping of the hepatic pedicle for 10 minutes.
Following this, ischemia-reperfusion of the pancreas was performed by first clam-ping the inferior splenic artery for 30 minutes, followed by reperfusion for one hour.
The rats were divided into three groups (10 rats in each group).
Group One was the sham operated group, without clamping of any artery.
Group-two developed ischemiareperfusion-induced pancreatitis, without ischemic pre-conditioning of the liver, while Group-three underwent ischemic pre-conditioning of the liver followed by ischemia-reperfusion of the pancreas.
Ischemic pre-conditioning, applied prior to induction of pancreatitis, caused a reduction in plasma lipase, plasma interleukin-1β and histological signs of pancreatic damage, but plasma interleukin-10 levels were not significantly different between the three groups.
Ischemic pre-conditioning of the liver did not cause any alteration of the liver enzymes.
Our study suggests that ischemic preconditioning of the liver reduces the severity of ischemia-reperfusion-induced pancreatitis.
These effects are partly related to the reduction of pro-inflammatory interleukin -1β.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Nikeghbalian, Sama& Mansoorian, Muhsin Rida& Husayn, Sayyid Muhammad Fahd& Mardani, Parviz& Gerami zadah, Bita& Malik Husayni, Sayyid Ali. 2009. Reduction of the severity of ischemia reperfusion-induced pancreatitis by ischemic pre-conditioning of the liver. Saudi Journal of Kidney Diseases and Transplantation،Vol. 20, no. 6, pp.1010-1014.
https://search.emarefa.net/detail/BIM-279690
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Nikeghbalian, Sama…[et al.]. Reduction of the severity of ischemia reperfusion-induced pancreatitis by ischemic pre-conditioning of the liver. Saudi Journal of Kidney Diseases and Transplantation Vol. 20, no. 6 (Dec. 2009), pp.1010-1014.
https://search.emarefa.net/detail/BIM-279690
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Nikeghbalian, Sama& Mansoorian, Muhsin Rida& Husayn, Sayyid Muhammad Fahd& Mardani, Parviz& Gerami zadah, Bita& Malik Husayni, Sayyid Ali. Reduction of the severity of ischemia reperfusion-induced pancreatitis by ischemic pre-conditioning of the liver. Saudi Journal of Kidney Diseases and Transplantation. 2009. Vol. 20, no. 6, pp.1010-1014.
https://search.emarefa.net/detail/BIM-279690
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 1014
رقم السجل
BIM-279690
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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