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A study on the association between Angiotensin-I converting enzyme I D dimorphism and type-2 diabetes mellitus
المؤلفون المشاركون
Chmaisse, Hania Nakkash
Jamal, Manal
Fakhuri, Rajaa
Fakhuri, Hana
المصدر
Saudi Journal of Kidney Diseases and Transplantation
العدد
المجلد 20، العدد 6 (31 ديسمبر/كانون الأول 2009)، ص ص. 1038-1046، 9ص.
الناشر
تاريخ النشر
2009-12-31
دولة النشر
السعودية
عدد الصفحات
9
التخصصات الرئيسية
الموضوعات
الملخص EN
Type-2 diabetes mellitus (T2DM) is a chronic disorder characterized by a varying range of predominant insulin resistance with relative insulin deficiency, to predominant insulin secretory defect with or without insulin resistance.
Familial clustering as well as epidemiological studies has shown that genetic factors play a role in the development and progression of the disease.
Among the genetic factors found to be associated with development of T2DM is the angiotensin-I converting enzyme (ACE) gene, which is located on chromosome 17q23.
This study was conducted to study the association between ACE gene insertion / deletion (I / D) polymorphism and T2DM in a Lebanese diabetic cohort.
Fifty-one patients with T2DM and 40 control subjects from different parts of Lebanon underwent genotyping for the ACE I / D, which was performed by PCR using specific primers.
Chi-square and analysis of variance (ANOVA) were used for association studies and to assess the differences in the values among the groups.
The distribution of the genotypes in the patients was as follows : 15 / 51 (29.4 %) were homozygous for deletion allele (DD genotype), 24 / 51 (47.1 %) were heterozygous (ID genotype), and 12 / 51 (23.5 %) were homozygous for insertion allele (II genotype).
Among the control subjects, 16 / 40 (40 %) were homozygous for deletion (DD genotype), 13 / 40 (32.5 %) were heterozygous (ID genotype), and 11/40 (27.5 %) were homozygous for insertion (II genotype).
The prevalence of the D-allele in T2DM patients (52.9 %) was not significantly different from that in the controls (56.3 %).
Thus, ACE I / D dimorphism cannot be considered a risk factor for T2DM in the Lebanese population.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Chmaisse, Hania Nakkash& Jamal, Manal& Fakhuri, Hana& Fakhuri, Rajaa. 2009. A study on the association between Angiotensin-I converting enzyme I D dimorphism and type-2 diabetes mellitus. Saudi Journal of Kidney Diseases and Transplantation،Vol. 20, no. 6, pp.1038-1046.
https://search.emarefa.net/detail/BIM-279720
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Chmaisse, Hania Nakkash…[et al.]. A study on the association between Angiotensin-I converting enzyme I D dimorphism and type-2 diabetes mellitus. Saudi Journal of Kidney Diseases and Transplantation Vol. 20, no. 6 (Dec. 2009), pp.1038-1046.
https://search.emarefa.net/detail/BIM-279720
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Chmaisse, Hania Nakkash& Jamal, Manal& Fakhuri, Hana& Fakhuri, Rajaa. A study on the association between Angiotensin-I converting enzyme I D dimorphism and type-2 diabetes mellitus. Saudi Journal of Kidney Diseases and Transplantation. 2009. Vol. 20, no. 6, pp.1038-1046.
https://search.emarefa.net/detail/BIM-279720
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 1044-1046
رقم السجل
BIM-279720
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
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