Mirazid alone or combined with paromomycin in treating cryptosporidiosis parvum in immunocompetent hospitalized patients

الملخص EN

Sixty cryptosporidiosis patients from Mansoura University Hospitals, 36 males and 24 females, with age from few months to ten years (mean age 6.1) were divided into three cross-matched groups of 20 patients each.

All patients received the glutamine-based oral rehyd-ration solution with 111 mmol / l glutamine, 20 mg zinc acetate once a day and vitamin A supplementation (200,000 IU) once a day for 2 weeks.

For cryptosporidiosis treatment, G1 received Mirazid® (10mg / kg for 2 weeks), G2 received Paromomycin® (500 mg qid for 2 wee-ks), and G3 received a combination of Mirazid (10mg / kg) and Parom-omycin (500 mg) for two weeks.

The result was assessed according to the scales : 0 = no improvement, 1 = symptoms began improvement (reduction of diarrhea frequency and stool volume, less abdominal pain, less nausea and vomiting), 2 = diarrhea eradication, 3 = weight gain, 4 = oocyst counts reduction, 5 = reduction in diarrhea and oocyst counts, 6= eradication of diarrhea and oocysts.

G3 showed significantly higher difference than G1 and G2 in the 1st week (p =.036, 0.025 res-pectively), no significant difference in 2nd week, a significantly higher difference than in G1 (0.003), and G2 (0.006) in 3rd week, and a significantly higher difference than G1 (0.014), and G2 (0.01) in 4th week, but without significant differences in oocyst shedding in the 3 groups.