![](/images/graphics-bg.png)
Effect of depot medroxyprogesterone (dmpa) on body weight and serum lipid profile in adult female rats
المؤلفون المشاركون
المصدر
The Egyptian Journal of Biochemistry and Molecular Biology
العدد
المجلد 27، العدد 1 (30 يونيو/حزيران 2009)، ص ص. 17-30، 14ص.
الناشر
الجمعية المصرية للكيمياء الحيوية و البيولوجيا الجزيئية
تاريخ النشر
2009-06-30
دولة النشر
مصر
عدد الصفحات
14
التخصصات الرئيسية
الموضوعات
الملخص EN
Depot Provera® ; (Medroxyprogesterone Acetate, DMPA) is a long acting, injectable progesterone derivative contraceptive that is currently used by 30 million women in 90 countries, including Egypt, United States and Canada.
DMPA classified as sex hormone binding globulin (SHBG).
The objective of this study was to investigate body weight and serum lipid profile following treatment of rats with the injectable contraceptive depot medroxyprogesterone acetate, (Depot Provera® ; DMPA).
Adult female rats (Rates novices) were treated with a single dose of DMPA that is comparable to the weight corrected dose in humans (2.7 mg / rat or 5.4 mg / rat) and sacrificed on day ten or fifteen post treatment.
Body weights were recorded and sera from both treated and control groups studied for lipid profile using a colorimetric method.
Treating animals with 2.7 mg / rat or 5.4 mg / rat of DMPA for 10 and 15 days led to a dose-related increase in the body weights (maximum ~ 24.77 %).
There was increase in total lipids (TL), triglycerides (TG), total cholesterol (TC) as well as low density lipoprotein cholesterol (LDL-C) and very low density lipoprotein (VLDL-C).
On the other hand, a marked decrease was found in high density-lipoprotein cholesterol (HDL-C) in the DMPA-treated groups.
Statistical analysis indicated that these changes were significant (p < 0.01) in all treated groups compared to control ones.
We concluded that, this preliminary study indicates a long-term atherogenic role for DMPA.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Bakri, S.& Abd Allah, A.. 2009. Effect of depot medroxyprogesterone (dmpa) on body weight and serum lipid profile in adult female rats. The Egyptian Journal of Biochemistry and Molecular Biology،Vol. 27, no. 1, pp.17-30.
https://search.emarefa.net/detail/BIM-28001
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Bakri, S.& Abd Allah, A.. Effect of depot medroxyprogesterone (dmpa) on body weight and serum lipid profile in adult female rats. The Egyptian Journal of Biochemistry and Molecular Biology Vol. 27, no. 1 (Jun. 2009), pp.17-30.
https://search.emarefa.net/detail/BIM-28001
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Bakri, S.& Abd Allah, A.. Effect of depot medroxyprogesterone (dmpa) on body weight and serum lipid profile in adult female rats. The Egyptian Journal of Biochemistry and Molecular Biology. 2009. Vol. 27, no. 1, pp.17-30.
https://search.emarefa.net/detail/BIM-28001
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references : p. 26-30
رقم السجل
BIM-28001
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
![](/images/ebook-kashef.png)
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
![](/images/kashef-image.png)