Systemic effect of tranexamic acid on prothrombin and clotting times in rabbits after IV injection : experimental study

الملخص EN

Aim : to evaluate the effect of a single dose of tranexamic acid (cyclokapron) in reducing the postoperative bleeding following minor oral surgery on ten rabbits on anticoagulant therapy (heparin).

Materials and Methods: Samples of blood were collected pre and post heparin and tranexamic acid injection for measuring the Prothrombin and clotting time.

Results : There was no significant difference between the Prothrombin time and clotting time normal and Prothrombin time and clotting time after tranexamic acid injection.

Conclusion : A single dose of tranexamic acid given postoperatively was effective in reducing the postoperative bleeding following minor oral surgery in experimental rabbit on heparin anticoagulant therapy without changing the regular heparin regimen doses.

The same regimen may be applied on hospitalized patient on heparin anticoagulant therapy.