Stereochemical analysis in 22-membered macrolides based on molecular modeling

الملخص EN

Conformational analysis of macrolides with 22-ring membered has been carried out using molecular modeling (molecular mechanics and molecular dynamics).

The results indicate that each investigated macrocycles present eight types of preferential conformations.

They result of the combination of two systems diene and ester a,(3-unsaturated.

A high conformational mobility of no complexed macrocycles (22) was obtained.

In presence of tricarbonyliron, the number of the privileged conformations was reduced.